Open Access

A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor

  • Authors:
    • Ping Ren
    • Meiling Hu
  • View Affiliations

  • Published online on: October 14, 2019     https://doi.org/10.3892/ol.2019.10990
  • Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The prognostic significance of long non‑coding RNAs (lncRNAs) in Wilms' tumor (WT) remains unclear. The present study identified differential lncRNA expression patterns between WT and normal tissues; and evaluated the prognostic value of these lncRNAs. Multidimensional data from 136 samples were retrieved from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Computational data analyses were performed to detect survival‑associated molecular signatures. Kaplan‑Meier survival curves revealed the prognostic prediction values for three of these lncRNAs, namely DLGAP1 antisense RNA 2 (DLGAP1‑AS2), RP11‑93B14.6 and RP11554F20.1. Cox regression analysis revealed that the three‑lncRNA signature was significantly associated with patient survival (P<0.01). Functional enrichment analyses suggested that the target genes of these three lncRNAs may be involved in known cancer‑associated pathways. The present study revealed a three‑lncRNA signature consisting of DLGAP1‑AS2, RP11‑93B14.6 and RP11554F20.1 that may be used as a prognostic marker for patients with WT.

Related Articles

Journal Cover

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Ren, P., & Ren, P. (1899). A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor. Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2019.10990
MLA
Ren, P., Hu, M."A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor". Oncology Letters 0.0 (1899): 0-0.
Chicago
Ren, P., Hu, M."A three long non‑coding RNA signature to improve survival prediction in patients with Wilms' tumor". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2019.10990