Open Access

Cytochrome C inhibits tumor growth and predicts favorable prognosis in clear cell renal cell carcinoma

  • Authors:
    • Zhiguo Liu
    • Xiancheng Zhao
    • Liang Zhang
    • Bing Pei
  • View Affiliations

  • Published online on: October 14, 2019     https://doi.org/10.3892/ol.2019.10989
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cytochrome C (Cyto C), a multifunctional enzyme, has been demonstrated to be associated with cell apoptosis and respiration. Accumulating evidence has revealed that serum Cyto C is an effective indicator in evaluating the effect of chemotherapy. However, to the best of our knowledge, the clinical significance of Cyto C and its role in cell growth and apoptosis in clear cell renal cell carcinoma (CCRCC) remain unknown. In the present study, Cyto C expression was detected in 150 CCRCC and 30 normal tissues samples via immunohistochemistry. The results demonstrated that Cyto C protein expression levels in CCRCC tissues were downregulated compared with those in corresponding normal tissues. In addition, it was revealed that Cyto C expression was negatively associated with TNM stage. Further analyses revealed that patients with CCRCC and low Cyto C expression levels had a shorter survival time than those with high Cyto C expression. Multivariate analyses indicated that high Cyto C expression levels were an independent prognostic factor for survival. Functionally, overexpression of Cyto C effectively suppressed the growth of CCRCC cells and induced cell apoptosis, and knockdown of Cyto C reversed these effects. Finally, overexpression of Cyto C inhibited the tumor growth of CCRCC cells in vivo. Overall, the data of the present study indicated that Cyto C may be a novel prognostic biomarker and acted as a regulator of tumor growth in CCRCC.

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Print ISSN: 1792-1074
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APA
Liu, Z., Zhao, X., Zhang, L., & Pei, B. (1899). Cytochrome C inhibits tumor growth and predicts favorable prognosis in clear cell renal cell carcinoma. Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2019.10989
MLA
Liu, Z., Zhao, X., Zhang, L., Pei, B."Cytochrome C inhibits tumor growth and predicts favorable prognosis in clear cell renal cell carcinoma". Oncology Letters 0.0 (1899): 0-0.
Chicago
Liu, Z., Zhao, X., Zhang, L., Pei, B."Cytochrome C inhibits tumor growth and predicts favorable prognosis in clear cell renal cell carcinoma". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2019.10989