The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)

  • Authors:
    • Changmei Chen
    • Xiang Gong
    • Xiaoxu Yang
    • Xianhui Shang
    • Qian Du
    • Qiushi Liao
    • Rui Xie
    • Yuanshou Chen
    • Jingyu Xu
  • View Affiliations

  • Published online on: October 11, 2019     https://doi.org/10.3892/ol.2019.10983
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Abstract

Estrogen is an important sex steroid hormone which serves an important role in the regulation of a number of biological functions, including regulating bone density, brain function, cholesterol mobilization, electrolyte balance, skin physiology, the cardiovascular system, the central nervous system and female reproductive organs. Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor α, estrogen receptor β and G protein‑coupled estrogen receptor 1. In recent years, researchers have demonstrated that estrogen and its receptors serve an important role in the gastrointestinal (GI) tract and contribute to the progression of a number of GI diseases, including gastroesophageal reflux, esophageal cancer, peptic ulcers, gastric cancer, inflammatory bowel disease, irritable bowel syndrome and colon cancer. The aim of this review is to provide an overview of estrogen and its receptors in GI disease, and highlight potential avenues for the prevention and treatment of GI diseases.

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Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q. ... Xu, J. (1899). The roles of estrogen and estrogen receptors in gastrointestinal disease (Review). Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2019.10983
MLA
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q., Xie, R., Chen, Y., Xu, J."The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)". Oncology Letters 0.0 (1899): 0-0.
Chicago
Chen, C., Gong, X., Yang, X., Shang, X., Du, Q., Liao, Q., Xie, R., Chen, Y., Xu, J."The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2019.10983