Open Access

Five extracellular matrix‑associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis

  • Authors:
    • Pingping Zhong
    • Liya Liu
    • Aling Shen
    • Zhongxin Chen
    • Xiaoyan Hu
    • Yichao Cai
    • Jie Lin
    • Bangyan Wang
    • Jiesen Li
    • Youqin Chen
    • Jun Peng
  • View Affiliations

  • Published online on: October 11, 2019     https://doi.org/10.3892/ol.2019.10982
  • Pages: 5959-5967
  • Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic marker for patients at a high risk of developing OTSCC. The present study used four original microarray datasets to identify the key candidate genes involved in OTSCC pathogenesis. Expression profiles of 93 OTSCC tissues and 76 normal tissues from GSE9844, GSE13601, GSE31056 and GSE75538 datasets were investigated. Differentially expressed genes (DEGs) were determined, and gene ontology enrichment and gene interactions were analyzed. The four GSE datasets reported five upregulated and six downregulated DEGs. Five upregulated genes (matrix metalloproteinase 1, 3, 10 and 12 and laminin subunit gamma 2) were localized in the extracellular region of cells and were associated with extracellular matrix disassembly. Furthermore, analysis for The Cancer Genome Atlas database revealed that the aforementioned five upregulated genes were also highly expressed in OTSCC and head and neck squamous cell carcinoma tissues. These results demonstrated that the five upregulated genes may be considered as potential prognostic biomarkers of OTSCC and may serve at understanding OTSCC progression. Upregulated DEGs may therefore represent valuable therapeutic targets to prevent or control OTSCC pathogenesis.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Zhong, P., Liu, L., Shen, A., Chen, Z., Hu, X., Cai, Y. ... Peng, J. (2019). Five extracellular matrix‑associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis. Oncology Letters, 18, 5959-5967. https://doi.org/10.3892/ol.2019.10982
MLA
Zhong, P., Liu, L., Shen, A., Chen, Z., Hu, X., Cai, Y., Lin, J., Wang, B., Li, J., Chen, Y., Peng, J."Five extracellular matrix‑associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis". Oncology Letters 18.6 (2019): 5959-5967.
Chicago
Zhong, P., Liu, L., Shen, A., Chen, Z., Hu, X., Cai, Y., Lin, J., Wang, B., Li, J., Chen, Y., Peng, J."Five extracellular matrix‑associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis". Oncology Letters 18, no. 6 (2019): 5959-5967. https://doi.org/10.3892/ol.2019.10982