Open Access

Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer (Review)

  • Authors:
    • Zhongjie Yu
    • Qi Li
    • Yi An
    • Xiatian Chen
    • Ziqian Liu
    • Zhe Li
    • Jinning Gao
    • Lynn Htet Htet Aung
    • Peifeng Li
  • View Affiliations

  • Published online on: October 11, 2019     https://doi.org/10.3892/ol.2019.10981
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Apoptosis repressor with caspase recruitment domain (ARC) is a potent inhibitor of apoptosis. Under physiological conditions, ARC is abundantly expressed in terminally differentiated cells, including cardiomyocytes, skeletal muscles and neurons. ARC serves a key role in determining cell fate, and abnormal ARC expression has been demonstrated to be associated with abnormal cell growth. Previous studies have revealed that ARC was upregulated in several different types of solid tumor, where it suppressed tumor cell apoptosis. Furthermore, the increased expression levels of ARC in cancer cells contributed to the development of therapeutic resistance and adverse clinical outcomes in patients with leukemia. However, the exact role of ARC, as well as the underlying molecular mechanisms involved, remain poorly understood. The present review summarizes the characteristics of ARC and its cytoprotective role under different conditions and describes the potential ARC as a new target for cancer therapy.

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Copy and paste a formatted citation
APA
Yu, Z., Li, Q., An, Y., Chen, X., Liu, Z., Li, Z. ... Li, P. (1899). Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer (Review). Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2019.10981
MLA
Yu, Z., Li, Q., An, Y., Chen, X., Liu, Z., Li, Z., Gao, J., Aung, L. H., Li, P."Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer (Review)". Oncology Letters 0.0 (1899): 0-0.
Chicago
Yu, Z., Li, Q., An, Y., Chen, X., Liu, Z., Li, Z., Gao, J., Aung, L. H., Li, P."Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer (Review)". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2019.10981