Molecular mechanism of Helicobacter pylori‑induced autophagy in gastric cancer (Review)

  • Authors:
    • Fan Zhang
    • Cong Chen
    • Jike Hu
    • Ruiliang Su
    • Junqiang Zhang
    • Zhijian Han
    • Hao Chen
    • Yumin Li
  • View Affiliations

  • Published online on: October 10, 2019     https://doi.org/10.3892/ol.2019.10976
  • Pages: 6221-6227
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Abstract

Helicobacter pylori (H. pylori) is a gram‑negative pathogen that colonizes gastric epithelial cells. The drug resistance rates of H. pylori have dramatically increased, causing persistent infections. Chronic infection by H. pylori is a critical cause of gastritis, peptic ulcers and even gastric cancer. In host cells, autophagy is stimulated to maintain cellular homeostasis following intracellular pathogen recognition by the innate immune defense system. However, H. pylori‑induced autophagy is not consistent during acute and chronic infection. Therefore, a deeper understanding of the association between H. pylori infection and autophagy in gastric epithelial cells could aid the understanding of the mechanisms of persistent infection and the identification of autophagy‑associated therapeutic targets for H. pylori infection. The present review describes the role of H. pylori and associated virulence factors in the induction of autophagy by different signaling pathways during acute infection. Additionally, the inhibition of autophagy in gastric epithelial cells during chronic infection was discussed. The present review summarized H. pylori‑mediated autophagy and provided insights into its mechanism of action, suggesting the induction of autophagy as a novel therapeutic target for persistent H. pylori infection.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhang, F., Chen, C., Hu, J., Su, R., Zhang, J., Han, Z. ... Li, Y. (2019). Molecular mechanism of Helicobacter pylori‑induced autophagy in gastric cancer (Review). Oncology Letters, 18, 6221-6227. https://doi.org/10.3892/ol.2019.10976
MLA
Zhang, F., Chen, C., Hu, J., Su, R., Zhang, J., Han, Z., Chen, H., Li, Y."Molecular mechanism of Helicobacter pylori‑induced autophagy in gastric cancer (Review)". Oncology Letters 18.6 (2019): 6221-6227.
Chicago
Zhang, F., Chen, C., Hu, J., Su, R., Zhang, J., Han, Z., Chen, H., Li, Y."Molecular mechanism of Helicobacter pylori‑induced autophagy in gastric cancer (Review)". Oncology Letters 18, no. 6 (2019): 6221-6227. https://doi.org/10.3892/ol.2019.10976