Open Access

Use of immunotherapy in the treatment of gastric cancer (Review)

  • Authors:
    • Luhong Yang
    • Yanxia Wang
    • Huafeng Wang
  • View Affiliations

  • Published online on: September 30, 2019     https://doi.org/10.3892/ol.2019.10935
  • Pages: 5681-5690
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, cancer immunotherapies have received considerable attention as a viable therapeutic option for GC. Specifically, the immune checkpoint inhibitors, chimeric antigen rector (CAR)‑T cells and tumor vaccines, represent immunotherapies that have exhibited promising effects in the treatment of GC. A number of clinical trials have employed either immuno‑oncology monotherapies or combination therapies to improve the overall survival time (OS) and objective response rate (ORR) of patients with GC. The current review presents a summary of the clinical effects of checkpoint inhibitors, including CAR‑T and tumor vaccines, in the treatment of GC.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Yang, L., Wang, Y., & Wang, H. (2019). Use of immunotherapy in the treatment of gastric cancer (Review). Oncology Letters, 18, 5681-5690. https://doi.org/10.3892/ol.2019.10935
MLA
Yang, L., Wang, Y., Wang, H."Use of immunotherapy in the treatment of gastric cancer (Review)". Oncology Letters 18.6 (2019): 5681-5690.
Chicago
Yang, L., Wang, Y., Wang, H."Use of immunotherapy in the treatment of gastric cancer (Review)". Oncology Letters 18, no. 6 (2019): 5681-5690. https://doi.org/10.3892/ol.2019.10935