Open Access

Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma

  • Authors:
    • Haifan Zou
    • Minjun Liao
    • Wentao Xu
    • Renzhi Yao
    • Weijia Liao
  • View Affiliations

  • Published online on: September 30, 2019     https://doi.org/10.3892/ol.2019.10932
  • Pages: 5879-5888
  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Branched chain amino acid transaminase 1 (BCAT1) catalyzes the production of glutamates and branched‑chain α‑ketoacids from branched chain amino acids, and a normal BCAT1 expression is associated with tumorigenesis. Sequencing data from public databases, including The Cancer Genome Atlas, was used to analyze BCAT1 expression and regulation networks for hepatocellular carcinoma (HCC). Expression and methylation were assessed using UALCAN analysis, and data from multiple datasets concerning the BCAT1 expression level and associated survival rates were further analyzed using HCCDB; interaction networks of biological function were constructed using GeneMANIA. LinkedOmics was used to indicate correlations between BCAT1 and any identified differentially expressed genes. Gene enrichment analysis of BCAT‑associated genes was conducted using the Web‑based Gene SeT AnaLysis Toolkit. The expression levels of BCAT1 were increased in patients with HCC and in most cases, the level of BCAT1 promoter methylation was reduced. Interaction network analysis suggested that BCAT1 was involved in ‘metabolism’, ‘carcinogenesis’ and the ‘immune response’ via numerous cancer‑associated pathways. The present study revealed the expression patterns and potential function networks of BCAT1 in HCC, providing insights for future research into the role of BCAT1 in hepatocarcinogenesis. In addition, the study provided researchers with a way to analyze the genes of interest so they can continue their research in the right direction.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zou, H., Liao, M., Xu, W., Yao, R., & Liao, W. (2019). Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma. Oncology Letters, 18, 5879-5888. https://doi.org/10.3892/ol.2019.10932
MLA
Zou, H., Liao, M., Xu, W., Yao, R., Liao, W."Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma". Oncology Letters 18.6 (2019): 5879-5888.
Chicago
Zou, H., Liao, M., Xu, W., Yao, R., Liao, W."Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma". Oncology Letters 18, no. 6 (2019): 5879-5888. https://doi.org/10.3892/ol.2019.10932