Open Access

Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma

  • Authors:
    • Weilong Zhang
    • Junyong Zhu
    • Xue He
    • Xiaoni Liu
    • Jinhang Li
    • Wei Li
    • Ping Yang
    • Jing Wang
    • Kai Hu
    • Xiuru Zhang
    • Xiru Li
    • Hongmei Jing
  • View Affiliations

  • Published online on: September 11, 2019     https://doi.org/10.3892/ol.2019.10850
  • Pages: 5119-5128
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Exosome complex (EXOSC) genes, which encode a multi‑protein intracellular complex, mediate the degradation of various types of RNA molecules. EXOSCs, also known as polymyositis/scleroderma complexes, exist in eukaryotic cells and archaea, and primarily mediate 3' to 5'mRNA degradation. However, how EXOSC genes are implicated in processes of B‑cell immune‑associated pathways and B‑cell tumorigenesis remains unclear. The present bioinformatics study indicated that 6 of 10 EXOSC genes, particularly the EXO.index, were able to predict the survival of patients with mantle cell lymphoma (MCL), by analyzing gene expression profiles of 123 patients with MCL from the Gene Expression Omnibus database. The results suggested that EXOSC gene expression may be a molecular marker for MCL. Compared with the whole transcript profile, patients with MCL with a high EXO.index exhibited poorer survival and decreased RNA levels, which was also verified in a second dataset. The EXOSC genes may be associated with DNA repair and B‑cell activation pathways, which may be the cause of poorer survival of patients with MCL.

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November 2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Zhang, W., Zhu, J., He, X., Liu, X., Li, J., Li, W. ... Jing, H. (2019). Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma. Oncology Letters, 18, 5119-5128. https://doi.org/10.3892/ol.2019.10850
MLA
Zhang, W., Zhu, J., He, X., Liu, X., Li, J., Li, W., Yang, P., Wang, J., Hu, K., Zhang, X., Li, X., Jing, H."Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma". Oncology Letters 18.5 (2019): 5119-5128.
Chicago
Zhang, W., Zhu, J., He, X., Liu, X., Li, J., Li, W., Yang, P., Wang, J., Hu, K., Zhang, X., Li, X., Jing, H."Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma". Oncology Letters 18, no. 5 (2019): 5119-5128. https://doi.org/10.3892/ol.2019.10850