Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review)

  • Authors:
    • Ye Yang
    • Yaping Zhu
    • Xiaowei Xi
  • View Affiliations

  • Published online on: June 26, 2018     https://doi.org/10.3892/ol.2018.9023
  • Pages: 2771-2776
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Hydrogen (H2) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic applications. H2 can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or saline to produce H2 water or H2‑rich saline. H2 selectively reduces oxidants of the detrimental reactive oxygen species (ROS), including hydroxyl radicals (·OH) and peroxynitrite (ONOO‑), which serve a causative role in the promotion of tumor cell proliferation, invasion and metastasis, but do not disturb metabolic oxidation‑reduction reactions in cell signaling. Compared with traditional antioxidants, H2 is a small molecule that can easily dissipate throughout the body and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H2 may involve correction of the oxidative/anti‑oxidative imbalance and suppression of inflammatory mediators. Therefore the present review will discuss the anti‑inflammatory and anti‑tumorigenic action of H2 via ROS.
View Figures
View References

Related Articles

Journal Cover

September 2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Yang, Y., Zhu, Y., & Xi, X. (2018). Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review). Oncology Letters, 16, 2771-2776. https://doi.org/10.3892/ol.2018.9023
MLA
Yang, Y., Zhu, Y., Xi, X."Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review)". Oncology Letters 16.3 (2018): 2771-2776.
Chicago
Yang, Y., Zhu, Y., Xi, X."Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review)". Oncology Letters 16, no. 3 (2018): 2771-2776. https://doi.org/10.3892/ol.2018.9023