CCR7 regulates ANO6 to promote migration of pancreatic ductal adenocarcinoma cells via the ERK signaling pathway

  • Authors:
    • Long Wang
    • Xiang‑Yun Zhao
    • Jin‑Shui Zhu
    • Ni‑Wei Chen
    • Hui‑Ning Fan
    • Wei Yang
    • Jing‑Hui Guo
  • View Affiliations

  • Published online on: June 13, 2018     https://doi.org/10.3892/ol.2018.8962
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Abstract

The increase in migratory ability of pancreatic ductal adenocarcinoma cells is a key event in the development of metastasis to the lymph nodes and distant organs. Although the C‑C motif chemokine receptor 7 (CCR7) and its ligand, C‑C motif chemokine ligand 21 (CCL21), have been revealed to serve an important role in tumor migration, their precise roles and potential underlying mechanisms remain largely unknown. The present study revealed that overexpression of CCR7 significantly promoted BxPC‑3 cell migration, accompanied by the induction of anoctamin 6 (ANO6) expression, indicating that ANO6 is a downstream target of CCR7 signaling. Furthermore, the level of phosphorylated extracellular signal‑regulated kinase (ERK) was significantly increased in CCR7‑overexpressing BxPC‑3 cells, indicating that ERK may be a potential mediator of CCR7‑regulated ANO6 expression in BxPC‑3 cells. To characterize the receptor‑mediated pathway, a specific ERK inhibitor, U0126, was used, which reduced BxPC‑3 cell migration and the expression of ANO6. In summary, the results of the present study demonstrate that CCR7 promoted BxPC‑3 cell migration by regulating ANO6 expression perhaps via activation of the ERK signaling pathway.

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Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, L., Zhao, X., Zhu, J., Chen, N., Fan, H., Yang, W., & Guo, J. (1899). CCR7 regulates ANO6 to promote migration of pancreatic ductal adenocarcinoma cells via the ERK signaling pathway. Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2018.8962
MLA
Wang, L., Zhao, X., Zhu, J., Chen, N., Fan, H., Yang, W., Guo, J."CCR7 regulates ANO6 to promote migration of pancreatic ductal adenocarcinoma cells via the ERK signaling pathway". Oncology Letters 0.0 (1899): 0-0.
Chicago
Wang, L., Zhao, X., Zhu, J., Chen, N., Fan, H., Yang, W., Guo, J."CCR7 regulates ANO6 to promote migration of pancreatic ductal adenocarcinoma cells via the ERK signaling pathway". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2018.8962