The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)

  • Authors:
    • Ha Thi Nguyen
    • Hong‑Quan Duong
  • View Affiliations

  • Published online on: May 9, 2018     https://doi.org/10.3892/ol.2018.8679
  • Pages: 9-18
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Abstract

Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma is caused by three major pathways: Microsatellite instability, chromosomal instability and CpG island methylator phenotype. A growing body of scientific evidences suggests that CRC is a heterogeneous disease, and genetic characteristics of the tumors determine their prognostic outcome and response to targeted therapies. Early diagnosis and effective targeted therapies based on a current knowledge of the molecular characteristics of CRC are essential to the successful treatment of CRC. Therefore, the present review summarized the current understanding of the molecular characteristics of CRC, and discussed its implications for diagnosis and targeted therapy.
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July 2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Nguyen, H.T., & Nguyen, H.T. (2018). The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review). Oncology Letters, 16, 9-18. https://doi.org/10.3892/ol.2018.8679
MLA
Nguyen, H. T., Duong, H."The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)". Oncology Letters 16.1 (2018): 9-18.
Chicago
Nguyen, H. T., Duong, H."The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy (Review)". Oncology Letters 16, no. 1 (2018): 9-18. https://doi.org/10.3892/ol.2018.8679