Chemoprevention with phosphatidylcholine non-steroidal anti-inflammatory drugs in vivo and in vitro

  • Authors:
    • Lenard M. Lichtenberger
    • Tri Phan
    • Dexing Fang
    • Elizabeth J. Dial
  • View Affiliations

  • Published online on: February 21, 2018     https://doi.org/10.3892/ol.2018.8098
  • Pages: 6688-6694
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Abstract

The chemopreventive activity of non-steroidal anti-inflammatory drugs (NSAIDs), particularly aspirin, has been well demonstrated in preclinical and clinical studies. However, the primary side effect from this class of drug is gastrointestinal (GI) bleeding, which has limited the widespread use of NSAIDs for the prevention of cancer. The development of GI‑safer NSAIDs, which are associated with phosphatidylcholine (PC) may provide a solution to this therapeutic problem. In the present study, the efficacy of two NSAIDs, aspirin and indomethacin, were compared using murine colon cancer cell line MC‑26. Each NSAID was assessed alone and in combination with PC, using in vitro and in vivo systems. The results reveal that the PC‑associated NSAIDs had a significantly higher degree of protection against cancer cell growth compared with the unmodified NSAIDs. It was also observed that Aspirin‑PC and Indomethacin‑PC prevented the metastatic spread of cancer cells in a syngeneic mouse model. These results support the potential use of PC‑NSAIDs for the chemoprevention of colorectal cancer.
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May 2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Lichtenberger, L.M., Phan, T., Fang, D., & Dial, E.J. (2018). Chemoprevention with phosphatidylcholine non-steroidal anti-inflammatory drugs in vivo and in vitro. Oncology Letters, 15, 6688-6694. https://doi.org/10.3892/ol.2018.8098
MLA
Lichtenberger, L. M., Phan, T., Fang, D., Dial, E. J."Chemoprevention with phosphatidylcholine non-steroidal anti-inflammatory drugs in vivo and in vitro". Oncology Letters 15.5 (2018): 6688-6694.
Chicago
Lichtenberger, L. M., Phan, T., Fang, D., Dial, E. J."Chemoprevention with phosphatidylcholine non-steroidal anti-inflammatory drugs in vivo and in vitro". Oncology Letters 15, no. 5 (2018): 6688-6694. https://doi.org/10.3892/ol.2018.8098