Open Access

Cancer associated fibroblasts: An essential role in the tumor microenvironment (Review)

  • Authors:
    • Leilei Tao
    • Guichun Huang
    • Haizhu Song
    • Yitian Chen
    • Longbang Chen
  • View Affiliations

  • Published online on: June 30, 2017     https://doi.org/10.3892/ol.2017.6497
  • Pages: 2611-2620
  • Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Fibroblasts in the tumor stroma are well recognized as having an indispensable role in carcinogenesis, including in the initiation of epithelial tumor formation. The association between cancer cells and fibroblasts has been highlighted in several previous studies. Regulation factors released from cancer‑associated fibroblasts (CAFs) into the tumor microenvironment have essential roles, including the support of tumor growth, angiogenesis, metastasis and therapy resistance. A mutual interaction between tumor‑induced fibroblast activation, and fibroblast‑induced tumor proliferation and metastasis occurs, thus CAFs act as tumor supporters. Previous studies have reported that by developing fibroblast‑targeting drugs, it may be possible to interrupt the interaction between fibroblasts and the tumor, thus resulting in the suppression of tumor growth, and metastasis. The present review focused on the reciprocal feedback loop between fibroblasts and cancer cells, and evaluated the potential application of anti‑CAF agents in the treatment of cancer.
View Figures
View References

Related Articles

Journal Cover

September 2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Tao, L., Huang, G., Song, H., Chen, Y., & Chen, L. (2017). Cancer associated fibroblasts: An essential role in the tumor microenvironment (Review). Oncology Letters, 14, 2611-2620. https://doi.org/10.3892/ol.2017.6497
MLA
Tao, L., Huang, G., Song, H., Chen, Y., Chen, L."Cancer associated fibroblasts: An essential role in the tumor microenvironment (Review)". Oncology Letters 14.3 (2017): 2611-2620.
Chicago
Tao, L., Huang, G., Song, H., Chen, Y., Chen, L."Cancer associated fibroblasts: An essential role in the tumor microenvironment (Review)". Oncology Letters 14, no. 3 (2017): 2611-2620. https://doi.org/10.3892/ol.2017.6497