A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

  • Authors:
    • Il Lae Jung
    • Ju Hye Lee
    • Se Chan Kang
  • View Affiliations

  • Published online on: July 10, 2015     https://doi.org/10.3892/ol.2015.3482
  • Pages: 1597-1604
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Abstract

It has previously been reported that cold water-extracts of Moringa oleifera leaf have anticancer activity against various human cancer cell lines, including non‑small cell lung cancer. In the present study, the anticancer activity of M. oleifera leaf extracts was investigated in human hepatocellular carcinoma HepG2 cells. By the analysis of apoptotic signals, including the induction of caspase or poly(ADP‑ribose) polymerase cleavage, and the Annexin V and terminal deoxynucleotidyl transferase‑mediated dUTP nick end labeling assays, it was demonstrated that M. oleifera leaf extracts induce the apoptosis of HepG2 cells. In the hollow fiber assay, oral administration of the leaf extracts significantly reduced (44‑52%) the proliferation of the HepG2 cells and A549 non‑small cell lung cancer cells. These results support the potential of soluble extracts of M. oleifera leaf as orally administered therapeutics for the treatment of human liver and lung cancers.
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September 2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Jung, I.L., Lee, J.H., & Kang, S.C. (2015). A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells. Oncology Letters, 10, 1597-1604. https://doi.org/10.3892/ol.2015.3482
MLA
Jung, I. L., Lee, J. H., Kang, S. C."A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells". Oncology Letters 10.3 (2015): 1597-1604.
Chicago
Jung, I. L., Lee, J. H., Kang, S. C."A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells". Oncology Letters 10, no. 3 (2015): 1597-1604. https://doi.org/10.3892/ol.2015.3482