Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review)

  • Authors:
    • Ziliang Jin
    • Weihua Jiang
    • Liwei Wang
  • View Affiliations

  • Published online on: February 12, 2015     https://doi.org/10.3892/ol.2015.2959
  • Pages: 1502-1508
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Abstract

Gastric cancer is one of leading causes of cancer‑related mortality worldwide and is a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis of gastric cancer, involving the alteration of pathogenesis, and invasion and metastasis. With the development of modern technologies, various novel biomarkers had been identified that appear to possess diagnostic and prognostic value; therefore, the present review describes our current knowledge of biomarkers for the early diagnosis and prognosis of gastric cancer. Classic biomarkers for gastric cancer diagnosis include carcinoembryonic antigen and cancer antigen 19‑9, while microRNA and DNA hypomethylation are proposed as novel biomarkers. Excluding classical biomarkers, biomarkers for determining the progression and prognosis of gastric cancer focus on targeting microRNAs, epigenetic alterations and genetic polymorphisms.
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April 2015
Volume 9 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Jin, Z., Jiang, W., & Wang, L. (2015). Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review). Oncology Letters, 9, 1502-1508. https://doi.org/10.3892/ol.2015.2959
MLA
Jin, Z., Jiang, W., Wang, L."Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review)". Oncology Letters 9.4 (2015): 1502-1508.
Chicago
Jin, Z., Jiang, W., Wang, L."Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review)". Oncology Letters 9, no. 4 (2015): 1502-1508. https://doi.org/10.3892/ol.2015.2959