Regulation of let-7 and its target oncogenes (Review)

  • Authors:
    • Xirui Wang
    • Lei Cao
    • Yingyi Wang
    • Xiefeng Wang
    • Ning Liu
    • Yongping You
  • View Affiliations

  • Published online on: February 14, 2012     https://doi.org/10.3892/ol.2012.609
  • Pages: 955-960
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of gene expression in cells. Several novel factors and feedback loops involved in the regulation of the synthesis of let-7 have been identified and additional let-7 target genes have been found. Let-7 has also been shown to be significantly correlated with the occurrence and development of cancer and the results of preliminary studies suggest that it is involved in the regulation of oncogenic pathways in numerous types of tumors. Let-7 is, therefore, a potential molecular target for tumor therapy. Thus, this review examined let-7 and the correlation between let-7 and oncogenic pathways in cancer.
View Figures
View References

Related Articles

Journal Cover

May 2012
Volume 3 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Wang, X., Cao, L., Wang, Y., Wang, X., Liu, N., & You, Y. (2012). Regulation of let-7 and its target oncogenes (Review). Oncology Letters, 3, 955-960. https://doi.org/10.3892/ol.2012.609
MLA
Wang, X., Cao, L., Wang, Y., Wang, X., Liu, N., You, Y."Regulation of let-7 and its target oncogenes (Review)". Oncology Letters 3.5 (2012): 955-960.
Chicago
Wang, X., Cao, L., Wang, Y., Wang, X., Liu, N., You, Y."Regulation of let-7 and its target oncogenes (Review)". Oncology Letters 3, no. 5 (2012): 955-960. https://doi.org/10.3892/ol.2012.609