Open Access

Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response

  • Authors:
    • Ming Yang
    • Genxiang Mao
    • Lili Ouyang
    • Chenhui Shi
    • Pengfei Hu
    • Shuwei Huang
  • View Affiliations

  • Published online on: December 17, 2019     https://doi.org/10.3892/mmr.2019.10891
  • Pages: 641-648
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Crocetin, a natural compound, has been demonstrated to exhibit beneficial effects in cardiovascular diseases. Previous studies demonstrated that crocetin reduced ischemia/reperfusion (I/R) injury by attenuating cytotoxicity and cellular apoptosis. However, the previous mechanistic studies did not fully elucidate its pharmacological effects on cardiac damage, especially I/R injury. The present study verified its cardioprotective effects in a Langendorff perfusion system, an ex vivo model of I/R. It was demonstrated that crocetin significantly attenuated the activities of pro‑inflammatory cytokines and nuclear factor erythroid‑2 related factor 2 (Nrf2)/heme oxygenase‑1 signaling. The present study provided novel insight that crocetin regulated the unfolded protein response (UPR) and decreased associated protein levels to protect the heart. Furthermore, it was identified that Nrf2 played a key role in the cardioprotective effect of crocetin by attenuating inflammation and the UPR.
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February 2020
Volume 21 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Yang, M., Mao, G., Ouyang, L., Shi, C., Hu, P., & Huang, S. (2020). Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response. Molecular Medicine Reports, 21, 641-648. https://doi.org/10.3892/mmr.2019.10891
MLA
Yang, M., Mao, G., Ouyang, L., Shi, C., Hu, P., Huang, S."Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response". Molecular Medicine Reports 21.2 (2020): 641-648.
Chicago
Yang, M., Mao, G., Ouyang, L., Shi, C., Hu, P., Huang, S."Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response". Molecular Medicine Reports 21, no. 2 (2020): 641-648. https://doi.org/10.3892/mmr.2019.10891