Open Access

Inhibition of calcineurin/NFATc4 signaling attenuates ventilator‑induced lung injury

  • Authors:
    • Min Li
    • Xiang‑Zhi Fang
    • Xiao‑Tian Liu
    • Yong‑Feng Zheng
    • Yun‑Bin Xie
    • Xiao‑Dong Ma
    • Yan Xia
    • Dong‑Hua Shao
  • View Affiliations

  • Published online on: November 26, 2019     https://doi.org/10.3892/mmr.2019.10851
  • Pages: 607-614
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ventilator‑induced lung injury (VILI) is a life‑threatening condition caused by the inappropriate use of mechanical ventilation (MV). However, the precise molecular mechanism inducing the development of VILI remains to be elucidated. In the present study, it was revealed that the calcineurin/NFATc4 signaling pathway mediates the expression of adhesion molecules and proinflammatory cytokines essential for the development of VILI. The present results revealed that a high tidal volume ventilation (HV) caused lung inflammation and edema in the alveolar walls and the infiltration of inflammatory cells. The calcineurin activity and protein expression in the lungs were increased in animals with VILI, and NFATc4 translocated into the nucleus following calcineurin activation. Furthermore, the translocation of NFATc4 and lung injury were prevented by a calcineurin inhibitor (CsA). Thus, the present results highlighted the critical role of the calcineurin/NFATc4 signaling pathway in VILI and suggest that this pathway coincides with the release of ICAM‑1, VCAM‑1, TNF‑α and IL‑1β.
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February 2020
Volume 21 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Li, M., Fang, X., Liu, X., Zheng, Y., Xie, Y., Ma, X. ... Shao, D. (2020). Inhibition of calcineurin/NFATc4 signaling attenuates ventilator‑induced lung injury. Molecular Medicine Reports, 21, 607-614. https://doi.org/10.3892/mmr.2019.10851
MLA
Li, M., Fang, X., Liu, X., Zheng, Y., Xie, Y., Ma, X., Xia, Y., Shao, D."Inhibition of calcineurin/NFATc4 signaling attenuates ventilator‑induced lung injury". Molecular Medicine Reports 21.2 (2020): 607-614.
Chicago
Li, M., Fang, X., Liu, X., Zheng, Y., Xie, Y., Ma, X., Xia, Y., Shao, D."Inhibition of calcineurin/NFATc4 signaling attenuates ventilator‑induced lung injury". Molecular Medicine Reports 21, no. 2 (2020): 607-614. https://doi.org/10.3892/mmr.2019.10851