Open Access

MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression

  • Authors:
    • Jun Yin
    • Chengyin Weng
    • Jieke Ma
    • Fanfan Chen
    • Yecai Huang
    • Mei Feng
  • View Affiliations

  • Published online on: September 13, 2017     https://doi.org/10.3892/mmr.2017.7481
0

Abstract

Previous studies have demonstrated that microRNAs (miRs) are important regulators involved in various cancers, including human glioblastoma (GBM). However, the underlying mechanism of miR‑1288 remains poorly understood, and its role in GBM has not been reported. The present study confirmed that miR‑1288 expression was markedly upregulated in GBM. Ectopic expression of miR‑1288 promoted the prolife­ration, colony formation and anchorage‑independent growth of GBM cells. Bioinformatics analysis coupled with western blotting and luciferase report assays also indicated that miR‑1288 promoted cell proliferation of GBM by targeting ubiquitin carboxyl‑terminal hydrolase (CYLD). Knockdown of CYLD expression reversed the cell proliferation promotion by miR‑1288‑in in GBM. These results suggest that the miR‑1288/CYLD axis may represent a potential therapeutic target for the treatment of GBM.

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Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
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APA
Yin, J., Weng, C., Ma, J., Chen, F., Huang, Y., & Feng, M. (1899). MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression. Molecular Medicine Reports, 0, 0-0. https://doi.org/10.3892/mmr.2017.7481
MLA
Yin, J., Weng, C., Ma, J., Chen, F., Huang, Y., Feng, M."MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression". Molecular Medicine Reports 0.0 (1899): 0-0.
Chicago
Yin, J., Weng, C., Ma, J., Chen, F., Huang, Y., Feng, M."MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression". Molecular Medicine Reports 0, no. 0 (1899): 0-0. https://doi.org/10.3892/mmr.2017.7481