Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats

  • Authors:
    • Xiaodong Feng
    • Shanli Yang
    • Jiao Liu
    • Jia Huang
    • Jun Peng
    • Jiumao Lin
    • Jing Tao
    • Lidian Chen
  • View Affiliations

  • Published online on: March 22, 2013     https://doi.org/10.3892/mmr.2013.1392
  • Pages: 1516-1522
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Abstract

Cognitive impairment is a serious mental deficit following stroke that severely affects the quality of life of stroke survivors. Nuclear factor‑κB (NF-κB)-mediated neuronal cell apoptosis is involved in the development of post-stroke cognitive impairment; therefore, it has become a promising target for the treatment of impaired cognition. Acupuncture at the Baihui (DU20) and Shenting (DU24) acupoints is commonly used in China to clinically treat post‑stroke cognitive impairment; however, the precise mechanism of its action is largely unknown. In the present study, we evaluated the therapeutic efficacy of electroacupuncture against post-stroke cognitive impairment and investigated the underlying molecular mechanisms using a rat model of focal cerebral ischemia-reperfusion (I/R) injury. Electroacupuncture at Baihui and Shenting was identified to significantly ameliorate neurological deficits and reduce cerebral infarct volume. Additionally, electroacupuncture improved learning and memory ability in cerebral I/R injured rats, demonstrating its therapeutic efficacy against post-stroke cognitive impairment. Furthermore, electroacupuncture significantly suppressed the I/R-induced activation of NF-κB signaling in ischemic cerebral tissues. The inhibitory effect of electroacupuncture on NF-κB activation led to the inhibition of cerebral cell apoptosis. Finally, electroacupuncture markedly downregulated the expression of pro-apoptotic Bax and Fas, two critical downstream target genes of the NF-κB pathway. Collectively, our findings suggest that inhibition of NF-κB‑mediated neuronal cell apoptosis may be one mechanism via which electroacupuncture at Baihui and Shenting exerts a therapeutic effect on post-stroke cognitive impairment.
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May 2013
Volume 7 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Feng, X., Yang, S., Liu, J., Huang, J., Peng, J., Lin, J. ... Chen, L. (2013). Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats. Molecular Medicine Reports, 7, 1516-1522. https://doi.org/10.3892/mmr.2013.1392
MLA
Feng, X., Yang, S., Liu, J., Huang, J., Peng, J., Lin, J., Tao, J., Chen, L."Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats". Molecular Medicine Reports 7.5 (2013): 1516-1522.
Chicago
Feng, X., Yang, S., Liu, J., Huang, J., Peng, J., Lin, J., Tao, J., Chen, L."Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injured rats". Molecular Medicine Reports 7, no. 5 (2013): 1516-1522. https://doi.org/10.3892/mmr.2013.1392