Effects of lithium on oxidative stress parameters in healthy subjects

  • Authors:
    • Rushaniya Khairova
    • Rohit Pawar
    • Giacomo Salvadore
    • Mario F. Juruena
    • Rafael T. de Sousa
    • Márcio G. Soeiro-de-Souza
    • Mirian Salvador
    • Carlos A. Zarate
    • Wagner F. Gattaz
    • Rodrigo Machado-Vieira
  • View Affiliations

  • Published online on: December 22, 2011     https://doi.org/10.3892/mmr.2011.732
  • Pages: 680-682
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Abstract

Increased neuronal oxidative stress (OxS) induces deleterious effects on signal transduction, structural plasticity and cellular resilience, mainly by inducing lipid peroxidation in membranes, proteins and genes. Major markers of OxS levels include the thiobarbituric acid reactive substances (TBARS) and the enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase. Lithium has been shown to prevent and/or reverse DNA damage, free-radical formation and lipid peroxidation in diverse models. This study evaluates OxS parameters in healthy volunteers prior to and following lithium treatment. Healthy volunteers were treated with lithium in therapeutic doses for 2-4 weeks. Treatment with lithium in healthy volunteers selectively altered SOD levels in all subjects. Furthermore, a significant decrease in the SOD/CAT ratio was observed following lithium treatment, wich was associated with decreased OxS by lowering hydrogen peroxide levels. This reduction in the SOD/CAT ratio may lead to lower OxS, indicated primarily by a decrease in the concentration of cell hydrogen peroxide. Overall, the present findings indicate a potential role for the antioxidant effects of lithium in healthy subjects, supporting its neuroprotective profile in bipolar disorder (BD) and, possibly, in neurodegenerative processes.

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March 2012
Volume 5 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
APA
Khairova, R., Pawar, R., Salvadore, G., Juruena, M.F., de Sousa, R.T., Soeiro-de-Souza, M.G. ... Machado-Vieira, R. (2012). Effects of lithium on oxidative stress parameters in healthy subjects. Molecular Medicine Reports, 5, 680-682. https://doi.org/10.3892/mmr.2011.732
MLA
Khairova, R., Pawar, R., Salvadore, G., Juruena, M. F., de Sousa, R. T., Soeiro-de-Souza, M. G., Salvador, M., Zarate, C. A., Gattaz, W. F., Machado-Vieira, R."Effects of lithium on oxidative stress parameters in healthy subjects". Molecular Medicine Reports 5.3 (2012): 680-682.
Chicago
Khairova, R., Pawar, R., Salvadore, G., Juruena, M. F., de Sousa, R. T., Soeiro-de-Souza, M. G., Salvador, M., Zarate, C. A., Gattaz, W. F., Machado-Vieira, R."Effects of lithium on oxidative stress parameters in healthy subjects". Molecular Medicine Reports 5, no. 3 (2012): 680-682. https://doi.org/10.3892/mmr.2011.732