Primary adrenal leiomyosarcoma: A case report

  • Authors:
    • Maria Sakellariou
    • Dionysios Dellaportas
    • Eirini Grapsa
    • Menelaos Tzikanoulas
    • Athanasios Dellis
    • Theodosios Theodosopoulos
    • Constantinos Nastos
  • View Affiliations

  • Published online on: January 24, 2020     https://doi.org/10.3892/mco.2020.1987
  • Pages: 317-320
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Abstract

Adrenal leiomyosarcomas are rare mesenchymal tumors of the suprarenal region that are usually diagnosed after they have reached a large size. We report the case of a 62‑year‑old male with an incidentally found left adrenal mass. Magnetic resonance imaging of the retroperitoneal space showed a heterogeneously enhanced mass, measuring 10x8.2 cm, with characteristics suspicious of malignancy. The patient underwent left radical adrenalectomy after the hormonal evaluation of the tumor due to the high probability of adrenocortical carcinoma. However, microscopic examination of the tumor showed a spindle cell sarcoma. Immunohistochemically the neoplastic cells were found positive for desmin and smooth muscle actin and the diagnosis of a well differentiated adrenal leiomyosarcoma was established. During follow‑up the patient presented an aggressive course as he developed bone, liver and pulmonary metastases early postoperatively, which were treated with radiation therapy and chemotherapy. The patient has progressive metastatic disease while on chemotherapy 31 months after surgery.
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April 2020
Volume 12 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Sakellariou, M., Dellaportas, D., Grapsa, E., Tzikanoulas, M., Dellis, A., Theodosopoulos, T., & Nastos, C. (2020). Primary adrenal leiomyosarcoma: A case report. Molecular and Clinical Oncology, 12, 317-320. https://doi.org/10.3892/mco.2020.1987
MLA
Sakellariou, M., Dellaportas, D., Grapsa, E., Tzikanoulas, M., Dellis, A., Theodosopoulos, T., Nastos, C."Primary adrenal leiomyosarcoma: A case report". Molecular and Clinical Oncology 12.4 (2020): 317-320.
Chicago
Sakellariou, M., Dellaportas, D., Grapsa, E., Tzikanoulas, M., Dellis, A., Theodosopoulos, T., Nastos, C."Primary adrenal leiomyosarcoma: A case report". Molecular and Clinical Oncology 12, no. 4 (2020): 317-320. https://doi.org/10.3892/mco.2020.1987