Lack of association between Screencell-detected circulating tumour cells and long‑term survival of patients undergoing surgery for non‑small cell lung cancer: A pilot clinical study
- James Barr
- Dimple Chudasama
- Alex Rice
- Emmanouil Karteris
- Vladimir Anikin
Affiliations: Department of Thoracic Surgery, Royal Brompton and Harefield NHS Foundation Trust, Harefield UB9 6JH, UK, Department of Biomedical Science, Brunel University, London UB8 3PH, UK
- Published online on: January 21, 2020 https://doi.org/10.3892/mco.2020.1981
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et al. This is an open access article distributed under the
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Circulating tumour cells (CTCs) are cancer cells of epithelial origin that are present in peripheral blood samples. ScreenCell detection of CTCs and the association with long term survival in non‑small cell lung cancer (NSCLC) patients was evaluated in the present study. A total of 33 patients undergoing surgical resection for NSCLC were recruited. Patients were followed up for 5‑years post‑operatively. Pre‑operative patient bloods samples were processed using ScreenCell. CTCs were detected in 26 (79%) patients. In patients who were positive for CTCs, a total of 9 (35%) patients succumbed to the disease, whereas in patients negative for CTCs, a total of 4 (57%) patients succumbed to the disease (P=0.29). No association was identified between positive CTCs and poorer survival (Chi‑squared 1.47, P=0.23; hazard ratio, 0.42; 95% confidence interval: 0.1‑1.7). The presence of CTCs detected with ScreenCell does not influence prognosis in patients with NSCLC that was operated on. The high rate of CTC detection is encouraging in supporting this technology to aid early lung cancer diagnosis.