Open Access

Association between interleukin gene polymorphisms and multiple myeloma susceptibility

  • Authors:
    • Muhamaad Naveed Shahzad
    • Iqra Ijaz
    • Syed Shah Zaman Haider Naqvi
    • Cheng Yan
    • Fanli Lin
    • Shutan Li
    • Chunlan Huang
  • View Affiliations

  • Published online on: January 16, 2020     https://doi.org/10.3892/mco.2020.1979
  • Pages: 212-224
  • Copyright: © Shahzad et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study performed a retrospective observational study in order to investigate the relationship between the interleukin family gene polymorphisms and risk of multiple myeloma (MM), based on sixteen case‑control studies that contained 2,597 patients with MM and 3,851 controls. The results demonstrated that the genotypes IL‑6 and IL‑1 GG increased the risk of MM by approximately 40.8 and 80.2% compared with the genotypes AA and CC [odds ratio (OR)=1.14, 95% confidence interval (CI), 0.88‑1.47, and OR=1.16, 95% CI, 0.61‑2.19; respectively]. The results also revealed a significant association between T:C polymorphism of the IL‑6 and IL‑10 and the risk of MM (TC/CC: OR=1.37, 95% CI, 0.88‑2.16 and TT/CC: OR=1.26, 95% CI, 0.77‑2.06, respectively). Additionally, no significant association was identified between the C:A polymorphisms of the IL‑6 (rs8192284) and IL‑10 (rs1800872) receptors and the overall risk of MM (P>0.05). G:C polymorphisms of the IL‑1β1464G>C and IL‑6572G>C significantly increased the risk of MM (P<0.05). However, it has been determined that there is a significant association between the C:T polymorphism of the IL‑1α‑889C>T and IL‑1β‑3737C>T and the risk of MM (P<0.001). Subgroup analysis revealed that the detection of G:A polymorphisms in the IL‑6 promoter (OR=1.05, 95% CI, 0.78‑1.44) is more accurate in MM samples of the Asian population (OR=1.24, 95% CI, 0.92‑1.74). In addition, no significant association was identified between the IL gene polymorphisms in MM samples categorized by ethnicity and the IL family type (P=0.27). These single nucleotide polymorphism loci may be the appropriate gene markers for gene screening and a promising therapeutic strategy in the prognostics of patients with MM.
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March 2020
Volume 12 Issue 3

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APA
Shahzad, M.N., Ijaz, I., Naqvi, S.S., Yan, C., Lin, F., Li, S., & Huang, C. (2020). Association between interleukin gene polymorphisms and multiple myeloma susceptibility. Molecular and Clinical Oncology, 12, 212-224. https://doi.org/10.3892/mco.2020.1979
MLA
Shahzad, M. N., Ijaz, I., Naqvi, S. S., Yan, C., Lin, F., Li, S., Huang, C."Association between interleukin gene polymorphisms and multiple myeloma susceptibility". Molecular and Clinical Oncology 12.3 (2020): 212-224.
Chicago
Shahzad, M. N., Ijaz, I., Naqvi, S. S., Yan, C., Lin, F., Li, S., Huang, C."Association between interleukin gene polymorphisms and multiple myeloma susceptibility". Molecular and Clinical Oncology 12, no. 3 (2020): 212-224. https://doi.org/10.3892/mco.2020.1979