Open Access

Cathepsin S as a target in gastric cancer (Review)

  • Authors:
    • Adriano Carneiro da Costa
    • Fernando Santa‑Cruz
    • Luiz Alberto Reis Mattos
    • Maria Améllia Rêgo Aquino
    • Camila Ramos Martins
    • Álvaro Antônio Bandeira Ferraz
    • José Luiz Figueiredo
  • View Affiliations

  • Published online on: December 3, 2019     https://doi.org/10.3892/mco.2019.1958
  • Pages: 99-103
  • Copyright: © da Costa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cathepsin S (Cat S) is a protein expressed in some epithelial cells, which appears to be associated with cancer metastasis and recurrence. The abnormal expression of Cat S has been reported to be associated with the progression of certain types of gastrointestinal neoplasms, including gastric cancer (GC). There is a need to identify novel biomarkers and therapeutic targets associated with the growth, invasion and migration of GC cells, in order to develop non‑invasive diagnostic and prognostic procedures and design new therapeutic approaches. The aim of the present study was to assess the association between Cat S and oncogenic processes implicated in the development of GC, focusing on the diagnostic and therapeutic potential of this molecule in GC. A search was conducted through the PubMed and Cochrane Central Register of Controlled Trials electronic databases for relevant literature published between 2003 and 2018, using the mesh terms ‘cathepsin S’ and ‘cancer’ and ‘gastric cancer’.
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February 2020
Volume 12 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
da Costa, A.C., Santa‑Cruz, F., Mattos, L.A., Aquino, M.A., Martins, C.R., Ferraz, Á.A., & Figueiredo, J.L. (2020). Cathepsin S as a target in gastric cancer (Review). Molecular and Clinical Oncology, 12, 99-103. https://doi.org/10.3892/mco.2019.1958
MLA
da Costa, A. C., Santa‑Cruz, F., Mattos, L. A., Aquino, M. A., Martins, C. R., Ferraz, Á. A., Figueiredo, J. L."Cathepsin S as a target in gastric cancer (Review)". Molecular and Clinical Oncology 12.2 (2020): 99-103.
Chicago
da Costa, A. C., Santa‑Cruz, F., Mattos, L. A., Aquino, M. A., Martins, C. R., Ferraz, Á. A., Figueiredo, J. L."Cathepsin S as a target in gastric cancer (Review)". Molecular and Clinical Oncology 12, no. 2 (2020): 99-103. https://doi.org/10.3892/mco.2019.1958