Open Access

Sustained virological response by direct‑acting antivirals reduces the recurrence risk of hepatitis C‑related hepatocellular carcinoma after curative treatment

  • Authors:
    • Kenji Imai
    • Koji Takai
    • Tatsunori Hanai
    • Atsushi Suetsugu
    • Makoto Shiraki
    • Masahito Shimizu
  • View Affiliations

  • Published online on: November 29, 2019     https://doi.org/10.3892/mco.2019.1956
  • Copyright: © Imai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to assess the suppressive effect of direct‑acting antivirals (DAAs) on hepatocellular carcinoma (HCC) recurrence following curative treatment, particularly compared with interferon (IFN)‑based therapy. Among 117 curative cases of HCV‑related initial HCC between 2006 and 2017 at Gifu University Hospital, 13 and 14 cases achieved a sustained virological response (SVR) by DAA‑ (DAA group) or IFN‑based therapies (IFN group), and 64 cases were not treated with any antiviral therapy (non‑treatment group). Recurrence‑free survival (RFS) following curative treatment in each group was analyzed using the Kaplan‑Meier method and log‑rank test. A Cox proportional hazards model was used to analyze the factors that affected RFS. Age was significantly lower and serum alanine aminotransferase level was significantly higher in the IFN group than in both the DAA and non‑treatment groups. There was a significant difference in RFS between the non‑treatment group and antiviral therapy groups, including the DAA (P=0.014) and IFN groups (P=0.009); however, no significant difference was identified in RFS between the DAA and IFN groups (P=0.564). SVR achieved by DAA [P=0.011; hazard ratio (HR), 0.222; 95% CI, 0.069‑0.758] or IFN therapy (P=0.007; HR, 0.327; 95% CI, 0.145‑0.742) was an independent factor for the prevention of HCC recurrence. SVR by DAA therapy exhibited an anti‑liver tumorigenesis effect equal to that of IFN‑based therapy and reduced the risk of HCC recurrence.

Related Articles

Journal Cover

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Imai, K., Takai, K., Hanai, T., Suetsugu, A., Shiraki, M., & Shimizu, M. (1899). Sustained virological response by direct‑acting antivirals reduces the recurrence risk of hepatitis C‑related hepatocellular carcinoma after curative treatment. Molecular and Clinical Oncology, 0, 0-0. https://doi.org/10.3892/mco.2019.1956
MLA
Imai, K., Takai, K., Hanai, T., Suetsugu, A., Shiraki, M., Shimizu, M."Sustained virological response by direct‑acting antivirals reduces the recurrence risk of hepatitis C‑related hepatocellular carcinoma after curative treatment". Molecular and Clinical Oncology 0.0 (1899): 0-0.
Chicago
Imai, K., Takai, K., Hanai, T., Suetsugu, A., Shiraki, M., Shimizu, M."Sustained virological response by direct‑acting antivirals reduces the recurrence risk of hepatitis C‑related hepatocellular carcinoma after curative treatment". Molecular and Clinical Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/mco.2019.1956