Open Access

Application of deep learning to the classification of uterine cervical squamous epithelial lesion from colposcopy images

  • Authors:
    • Yasunari Miyagi
    • Kazuhiro Takehara
    • Takahito Miyake
  • View Affiliations

  • Published online on: October 4, 2019     https://doi.org/10.3892/mco.2019.1932
  • Pages: 583-589
  • Copyright: © Miyagi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to explore the feasibility of using deep learning as artificial intelligence (AI) to classify cervical squamous epithelial lesions (SIL) from colposcopy images. A total of 330 patients who underwent colposcopy and biopsy by gynecologic oncologists were enrolled in the current study. A total of 97 patients received a pathological diagnosis of low‑grade SIL (LSIL) and 213 of high‑grade SIL (HSIL). An original AI‑classifier with 11 layers of the convolutional neural network was developed and trained. The accuracy, sensitivity, specificity and Youden's J index of the AI‑classifier and oncologists for diagnosing HSIL were 0.823 and 0.797, 0.800 and 0.831, 0.882 and 0.773, and 0.682 and 0.604, respectively. The area under the receiver‑operating characteristic curve was 0.826±0.052 (mean ± standard error), and the 95% confidence interval 0.721‑0.928. The optimal cut‑off point was 0.692. Cohen's Kappa coefficient for AI and colposcopy was 0.437 (P<0.0005). The AI‑classifier performed better than oncologists, although not significantly. Although further study is required, the clinical use of AI for the classification of HSIL/LSIL from by colposcopy may be feasible.

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December 2019
Volume 11 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
APA
Miyagi, Y., Takehara, K., & Miyake, T. (2019). Application of deep learning to the classification of uterine cervical squamous epithelial lesion from colposcopy images. Molecular and Clinical Oncology, 11, 583-589. https://doi.org/10.3892/mco.2019.1932
MLA
Miyagi, Y., Takehara, K., Miyake, T."Application of deep learning to the classification of uterine cervical squamous epithelial lesion from colposcopy images". Molecular and Clinical Oncology 11.6 (2019): 583-589.
Chicago
Miyagi, Y., Takehara, K., Miyake, T."Application of deep learning to the classification of uterine cervical squamous epithelial lesion from colposcopy images". Molecular and Clinical Oncology 11, no. 6 (2019): 583-589. https://doi.org/10.3892/mco.2019.1932