Malignant peritoneal mesothelioma diagnosed 50 years post‑radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case

  • Authors:
    • Maki Ohya
    • Mikiko Kobayashi
    • Toshiro Sozuki
    • Hiroyuki Kanno
    • Koh Nakazawa
  • View Affiliations

  • Published online on: August 2, 2019     https://doi.org/10.3892/mco.2019.1906
  • Pages: 397-400
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Abstract

As the number of long‑term cancer survivors is increasing, the incidence of post‑irradiation malignant mesothelioma may also increase. We herein present the case of an 85‑year‑old female patient with a history of several surgeries for solid tumors and radiotherapy to the pelvis, who presented with abdominal pain and diarrhea. The patient's general condition gradually worsened and she succumbed to cardiopulmonary arrest triggered by vomiting ~3 months after the onset of the abdominal symptoms. An autopsy revealed malignant intestinal obstruction caused by peritoneal mesothelioma. Irradiation is a known risk factor for malignant mesothelioma, which may develop ~10‑30 years after radiotherapy. To the best of our knowledge, this is the first report of a patient with malignant mesothelioma developing ~50 years after radiotherapy. The aim of the present study was to remind physicians that malignant mesothelioma should be considered in the differential diagnosis of patients with a history of radiotherapy who present with gastrointestinal symptoms.

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October 2019
Volume 11 Issue 4

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Online ISSN:2049-9469

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Copy and paste a formatted citation
APA
Ohya, M., Kobayashi, M., Sozuki, T., Kanno, H., & Nakazawa, K. (2019). Malignant peritoneal mesothelioma diagnosed 50 years post‑radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case. Molecular and Clinical Oncology, 11, 397-400. https://doi.org/10.3892/mco.2019.1906
MLA
Ohya, M., Kobayashi, M., Sozuki, T., Kanno, H., Nakazawa, K."Malignant peritoneal mesothelioma diagnosed 50 years post‑radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case". Molecular and Clinical Oncology 11.4 (2019): 397-400.
Chicago
Ohya, M., Kobayashi, M., Sozuki, T., Kanno, H., Nakazawa, K."Malignant peritoneal mesothelioma diagnosed 50 years post‑radiotherapy for ovarian cancer in a patient with a history of multiple malignancies: An autopsy case". Molecular and Clinical Oncology 11, no. 4 (2019): 397-400. https://doi.org/10.3892/mco.2019.1906