Open Access

An updated review of mucosal melanoma: Survival meta‑analysis

  • Authors:
    • Hyung Min Hahn
    • Kyoung Geun Lee
    • Won Choi
    • Seung Hyun Cheong
    • Ki Bum Myung
    • Hyung Jin Hahn
  • View Affiliations

  • Published online on: May 29, 2019     https://doi.org/10.3892/mco.2019.1870
  • Pages: 116-126
  • Copyright: © Hahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mucosal melanoma (MM) is a highly lethal variant of melanoma that carries a poor prognosis. Extremely low incidence and survival rates have led to few clinical trials, and a lack of protocols and guidelines. The present study performed a survival meta‑analysis for the quantitative synthesis of available evidence to search for key patterns that would help clinicians tailor optimal therapeutic strategies in MM. PubMed, EMBASE, Cochrane, MEDLINE, Google Scholar and other databases were searched. Hazard ratios, in disease‑specific and overall survival, were calculated for each of the survival‑determining variables. MM was 2.25 times more lethal than cutaneous melanoma (CM). The most significant threats to survival were advanced Tumor‑Node‑Metastasis stage, sino‑nasal location, and old age. Chemotherapy was the most effective form of adjuvant therapy. Disease‑specific survival, the primary measure of the effect sizes, can fluctuate depending on the accuracy of the reported cause of mortality. In conclusion, MM is a peculiar type of melanoma, with clinical and molecular profile vastly different from the much‑familiar CM. In the wake of the era of precision oncology, further studies on driver mutations and oncogenic pathways would likely lead to improved patient survival.
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August 2019
Volume 11 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Hahn, H.M., Lee, K.G., Choi, W., Cheong, S.H., Myung, K.B., & Hahn, H.J. (2019). An updated review of mucosal melanoma: Survival meta‑analysis. Molecular and Clinical Oncology, 11, 116-126. https://doi.org/10.3892/mco.2019.1870
MLA
Hahn, H. M., Lee, K. G., Choi, W., Cheong, S. H., Myung, K. B., Hahn, H. J."An updated review of mucosal melanoma: Survival meta‑analysis". Molecular and Clinical Oncology 11.2 (2019): 116-126.
Chicago
Hahn, H. M., Lee, K. G., Choi, W., Cheong, S. H., Myung, K. B., Hahn, H. J."An updated review of mucosal melanoma: Survival meta‑analysis". Molecular and Clinical Oncology 11, no. 2 (2019): 116-126. https://doi.org/10.3892/mco.2019.1870