Open Access

Efficacy of combination therapy with zoledronic acid and cetuximab for unresectable rectal cancer with bone metastases: A case report

  • Authors:
    • Yoshihisa Tokumaru
    • Nobuhisa Matsuhashi
    • Takao Takahashi
    • Toshiyuki Tanahashi
    • Satoshi Matsui
    • Hisashi Imai
    • Yoshihiro Tanaka
    • Kazuya Yamaguchi
    • Kazuhiro Yoshida
  • View Affiliations

  • Published online on: April 3, 2019     https://doi.org/10.3892/mco.2019.1836
  • Pages: 571-574
  • Copyright: © Tokumaru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The combination of cetuximab (CTX) and chemotherapy, such as FOLFOX or FOLFIRI, is currently the standard treatment for metastatic colorectal cancer (mCRC). Zoledronic acid (ZOL) is used in patients with bone metastasis. We herein report our experience with the case of a 58‑year‑old male patient with metastatic rectal cancer who was treated with ZOL + CTX as third‑line therapy, and in whom this combination appeared to be effective. Although the patient developed bone metastasis and cardiac tamponade due to the recurrence of rectal cancer, he survived for approximately 10 months after the initiation of ZOL and CTX treatment.
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June 2019
Volume 10 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
APA
Tokumaru, Y., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H. ... Yoshida, K. (2019). Efficacy of combination therapy with zoledronic acid and cetuximab for unresectable rectal cancer with bone metastases: A case report. Molecular and Clinical Oncology, 10, 571-574. https://doi.org/10.3892/mco.2019.1836
MLA
Tokumaru, Y., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H., Tanaka, Y., Yamaguchi, K., Yoshida, K."Efficacy of combination therapy with zoledronic acid and cetuximab for unresectable rectal cancer with bone metastases: A case report". Molecular and Clinical Oncology 10.6 (2019): 571-574.
Chicago
Tokumaru, Y., Matsuhashi, N., Takahashi, T., Tanahashi, T., Matsui, S., Imai, H., Tanaka, Y., Yamaguchi, K., Yoshida, K."Efficacy of combination therapy with zoledronic acid and cetuximab for unresectable rectal cancer with bone metastases: A case report". Molecular and Clinical Oncology 10, no. 6 (2019): 571-574. https://doi.org/10.3892/mco.2019.1836