The Elental® elemental diet for chemoradiotherapy‑induced oral mucositis: A prospective study in patients with oral squamous cell carcinoma

  • Authors:
    • Koji Harada
    • Haruyasu Minami
    • Tarannum Ferdous
    • Yoshiaki Kato
    • Hirotsugu Umeda
    • Daiju Horinaga
    • Kenichiro Uchida
    • Sung Chul Park
    • Hideki Hanazawa
    • Shotaro Takahashi
    • Misaki Ohota
    • Hiromi Matsumoto
    • Junko Maruta
    • Hiromi Kakutani
    • Sanae Aritomi
    • Keiko Shibuya
    • Katsuaki Mishima
  • View Affiliations

  • Published online on: November 16, 2018     https://doi.org/10.3892/mco.2018.1769
  • Pages: 159-167
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Abstract

Oral mucositis is a common adverse effect of cancer treatment that can increase the risk for local and systemic infection. This prospective study was designed to evaluate the preventive effects of an amino‑acid‑rich elemental diet (ED), Elental®, on radiotherapy‑ or chemoradiotherapy‑induced mucositis in oral squamous cell carcinoma (OSCC) patients. Fifty patients were enrolled in this prospective study, who had received radiation (60‑70 Gy) with/without chemotherapy [S‑1, UFT, cisplatin (CDDP), docetaxel (DOC) plus CDDP, or Cetuximab]. The Elental® group (25 patients) had received Elental® during treatment, and the control group (25 patients) had not. Multivariate logistic regression analysis was used to identify the factors related to abatement of oral mucositis. A comparison of the rates of completion of chemoradiation treatments as well as the nutritional or inflammatory status between Elental® and control groups was performed. Multivariate analysis indicated that most of the patients who received Elental® suffered from a lower degree of mucositis and showed significantly improved rate of completion of chemoradiation (no interruption) compared to the control group. There was a significant difference between the Elental® group and the control group in terms of the mean change of C‑reactive protein (CRP) levels in blood serum; however, there was no significant difference in terms of a mean change of body weight and total protein level in blood serum before and after chemoradiation. Our study shows that the Elental® elemental diet could be useful for the treatment of oral mucositis induced by chemoradiation. Elental® might also promote improved completion rates of chemoradiotherapy in OSCC patients.
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January 2019
Volume 10 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Harada, K., Minami, H., Ferdous, T., Kato, Y., Umeda, H., Horinaga, D. ... Mishima, K. (2019). The Elental® elemental diet for chemoradiotherapy‑induced oral mucositis: A prospective study in patients with oral squamous cell carcinoma. Molecular and Clinical Oncology, 10, 159-167. https://doi.org/10.3892/mco.2018.1769
MLA
Harada, K., Minami, H., Ferdous, T., Kato, Y., Umeda, H., Horinaga, D., Uchida, K., Park, S. C., Hanazawa, H., Takahashi, S., Ohota, M., Matsumoto, H., Maruta, J., Kakutani, H., Aritomi, S., Shibuya, K., Mishima, K."The Elental® elemental diet for chemoradiotherapy‑induced oral mucositis: A prospective study in patients with oral squamous cell carcinoma". Molecular and Clinical Oncology 10.1 (2019): 159-167.
Chicago
Harada, K., Minami, H., Ferdous, T., Kato, Y., Umeda, H., Horinaga, D., Uchida, K., Park, S. C., Hanazawa, H., Takahashi, S., Ohota, M., Matsumoto, H., Maruta, J., Kakutani, H., Aritomi, S., Shibuya, K., Mishima, K."The Elental® elemental diet for chemoradiotherapy‑induced oral mucositis: A prospective study in patients with oral squamous cell carcinoma". Molecular and Clinical Oncology 10, no. 1 (2019): 159-167. https://doi.org/10.3892/mco.2018.1769