Open Access

Invasive Paget's disease of the vulva treated with a combination of surgery and concurrent chemoradiotherapy: A case report

  • Authors:
    • Yoshihide Inayama
    • Kaoru Abiko
    • Taito Miyamoto
    • Akihito Horie
    • Ken Yamaguchi
    • Tsukasa Baba
    • Noriomi Matsumura
    • Sachiko Minamiguchi
    • Masaki Mandai
  • View Affiliations

  • Published online on: September 17, 2018     https://doi.org/10.3892/mco.2018.1719
  • Pages: 489-489
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Abstract

Invasive Paget's disease of the vulva (IP) is rare among patients with vulvar cancer. Radiation therapy and chemotherapy are not considered as radical, whereas surgical resection of the tumor with abdominal lymphadenectomy is highly invasive. Thus, more effective and less invasive treatments for IP are required. The present study reports a case of a 64‑year‑old woman with IP, who was treated with a combination of surgery and concurrent chemoradiotherapy (CCRT). The patient was diagnosed with IP with suspected lymph node metastases to the inguinal and pelvic lymph nodes, after having suffered from pruritus vulvae for 7 years. Following mapping biopsy, wide local excision, bilateral inguinal lymph node resection and laparoscopic pelvic lymphadenectomy were successfully performed. The vulva was reconstructed with a local fat flap. Postoperative pathological examination revealed metastases to the bilateral superficial inguinal and the left obturator and lateral suprainguinal lymph nodes. Adjuvant CCRT (whole pelvic irradiation, 50.4 Gy with weekly cisplatin, 40 mg/m2) was completed without notable complications. Therefore, laparoscopic pelvic lymphadenectomy may be useful in determining the irradiation field for adjuvant CCRT in patients with advanced IP.
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November 2018
Volume 9 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Inayama, Y., Abiko, K., Miyamoto, T., Horie, A., Yamaguchi, K., Baba, T. ... Mandai, M. (2018). Invasive Paget's disease of the vulva treated with a combination of surgery and concurrent chemoradiotherapy: A case report. Molecular and Clinical Oncology, 9, 489-489. https://doi.org/10.3892/mco.2018.1719
MLA
Inayama, Y., Abiko, K., Miyamoto, T., Horie, A., Yamaguchi, K., Baba, T., Matsumura, N., Minamiguchi, S., Mandai, M."Invasive Paget's disease of the vulva treated with a combination of surgery and concurrent chemoradiotherapy: A case report". Molecular and Clinical Oncology 9.5 (2018): 489-489.
Chicago
Inayama, Y., Abiko, K., Miyamoto, T., Horie, A., Yamaguchi, K., Baba, T., Matsumura, N., Minamiguchi, S., Mandai, M."Invasive Paget's disease of the vulva treated with a combination of surgery and concurrent chemoradiotherapy: A case report". Molecular and Clinical Oncology 9, no. 5 (2018): 489-489. https://doi.org/10.3892/mco.2018.1719