Challenges in the management of neuroendocrine cervical cancer during pregnancy: A case report

  • Authors:
    • Blanca Gil‑Ibañez
    • Purificacion Regueiro
    • Elisa Llurba
    • Lorena Fariñas‑Madrid
    • Angel Garcia
    • Berta Diaz‑Feijoo
  • View Affiliations

  • Published online on: September 13, 2018     https://doi.org/10.3892/mco.2018.1717
  • Pages: 519-522
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Abstract

Large‑cell neuroendocrine carcinoma (LCNEC) is an uncommon histological subtype of cervical cancer that is associated with poor survival and its occurrence during pregnancy is particularly rare. We herein present the case of a female patient who was diagnosed with cervical LCNEC during pregnancy. The patient declined pregnancy termination and was treated with neoadjuvant chemotherapy with cisplatin and etoposide, without associated toxicity and with good fetal development. At 31.4 weeks of gestation, the fetus was delivered by caesarean section, and the patient underwent radical nerve‑sparing hysterectomy with bilateral adnexectomy, along with pelvic and inframesenteric para‑aortic lymphadenectomy. The patient received adjuvant chemoradiotherapy and there was no evidence of recurrence or metastasis at 38 months postoperatively. The baby has also been followed up, without any signs of neurodevelopmental disorders. To the best of our knowledge, the present report describes the first case of LCNEC with pregnancy‑preserving management in the literature to date.
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November 2018
Volume 9 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Gil‑Ibañez, B., Regueiro, P., Llurba, E., Fariñas‑Madrid, L., Garcia, A., & Diaz‑Feijoo, B. (2018). Challenges in the management of neuroendocrine cervical cancer during pregnancy: A case report. Molecular and Clinical Oncology, 9, 519-522. https://doi.org/10.3892/mco.2018.1717
MLA
Gil‑Ibañez, B., Regueiro, P., Llurba, E., Fariñas‑Madrid, L., Garcia, A., Diaz‑Feijoo, B."Challenges in the management of neuroendocrine cervical cancer during pregnancy: A case report". Molecular and Clinical Oncology 9.5 (2018): 519-522.
Chicago
Gil‑Ibañez, B., Regueiro, P., Llurba, E., Fariñas‑Madrid, L., Garcia, A., Diaz‑Feijoo, B."Challenges in the management of neuroendocrine cervical cancer during pregnancy: A case report". Molecular and Clinical Oncology 9, no. 5 (2018): 519-522. https://doi.org/10.3892/mco.2018.1717