Efficacy of vemurafenib in a heavy smoker with BRAF-mutated lung adenocarcinoma: A case report and literature review

  • Authors:
    • Xue Liu
    • Xuefeng Fang
    • Hanguang Hu
    • Xianhua Fu
    • Ying Chen
    • Ying Yuan
  • View Affiliations

  • Published online on: August 6, 2018     https://doi.org/10.3892/mco.2018.1691
  • Pages: 472-476
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Abstract

At present, research on BRAF gene mutations appears to be mainly focused on melanoma rather than non-small-cell lung cancer (NSCLC). We herein describe the case of a patient with BRAF V600E-mutated advanced NSCLC, whose symptoms were relieved and computed tomography imaging revealed partial response to vemurafenib following failure of chemotherapy. This case demonstrates the promising prospects of BRAF inhibitor treatment in patients with BRAF-mutated NSCLC. Targeted therapies have significantly modified the treatment of NSCLC. However, tumor tissue is frequently hard to obtain, whereas the coincidence rate of gene mutations between the plasma and tumor tissue is 60-80%. Therefore, in cases where tumor tissue is difficult to obtain, plasma next-generation sequencing may be used to detect gene mutations, which can overcome the limitations of gene detection. Furthermore, due to the tumor heterogeneity, different patients exhibit different gene mutation abundance. Research has demonstrated that mutation abundance is associated with the therapeutic efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors. However, the association between BRAF mutation abundance and the therapeutic effect of BRAF inhibitors requires further verification.
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October 2018
Volume 9 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Liu, X., Fang, X., Hu, H., Fu, X., Chen, Y., & Yuan, Y. (2018). Efficacy of vemurafenib in a heavy smoker with BRAF-mutated lung adenocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 9, 472-476. https://doi.org/10.3892/mco.2018.1691
MLA
Liu, X., Fang, X., Hu, H., Fu, X., Chen, Y., Yuan, Y."Efficacy of vemurafenib in a heavy smoker with BRAF-mutated lung adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 9.4 (2018): 472-476.
Chicago
Liu, X., Fang, X., Hu, H., Fu, X., Chen, Y., Yuan, Y."Efficacy of vemurafenib in a heavy smoker with BRAF-mutated lung adenocarcinoma: A case report and literature review". Molecular and Clinical Oncology 9, no. 4 (2018): 472-476. https://doi.org/10.3892/mco.2018.1691