Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report

  • Authors:
    • Shun Yin Kong
    • Wing Kit Lam
    • Ka Shu Li
    • Ka Pik Yeung
    • Chung Yin Ha
    • Ho Kei Lai
    • Hay Nun Chan
    • Yiu Ming Yeung
    • Sze Fai Yip
  • View Affiliations

  • Published online on: April 24, 2018     https://doi.org/10.3892/mco.2018.1612
  • Pages: 757-759
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

t(11;14) translocation is one of the most common chromosomal abnormalities in plasma cell myeloma. The present case report presented a case of plasma cell myeloma with t(11;14) translocation, in which the plasma cells were small lymphoplasmacytoids in morphology with positive cluster of differentiation-20 and Cyclin D1 expression. These results led to initial diagnostic difficulties. The patient was refractory to bortezomib-based therapy, and responsive to vincristine, doxorubicin and dexamethasone. However, the prognostic value of t(11;14) in plasma cell myeloma remains to be determined. With recent advances in treatment options, physicians should be aware of the clinical and pathological characteristics of this translocation in plasma cell myeloma.
View Figures
View References

Related Articles

Journal Cover

June 2018
Volume 8 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H. ... Yip, S. (2018). Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report. Molecular and Clinical Oncology, 8, 757-759. https://doi.org/10.3892/mco.2018.1612
MLA
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H., Chan, H., Yeung, Y., Yip, S."Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report". Molecular and Clinical Oncology 8.6 (2018): 757-759.
Chicago
Kong, S., Lam, W., Li, K., Yeung, K., Ha, C., Lai, H., Chan, H., Yeung, Y., Yip, S."Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report". Molecular and Clinical Oncology 8, no. 6 (2018): 757-759. https://doi.org/10.3892/mco.2018.1612