Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report

  • Authors:
    • Noriyuki Horiguchi
    • Tomomitsu Tahara
    • Tomohiko Kawamura
    • Masaaki Okubo
    • Takamitsu Ishizuka
    • Naoko Nakano
    • Yoshihito Nakagawa
    • Mitsuo Nagasaka
    • Mitsuru Nakagawa
    • Tetsuya Tsukamoto
    • Tomoyuki Shibata
    • Naoki Ohmiya
  • View Affiliations

  • Published online on: March 5, 2018     https://doi.org/10.3892/mco.2018.1586
  • Pages: 657-660
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Abstract

Epstein-Barr virus (EBV) infection is involved in a subset of gastric carcinoma (GC) cases, and is associated with distinct clinicopathological features. The present study reports a unique case of EBV‑associated early‑stage GC compared with the other cases experienced in our hospital. A 72‑year‑old male receiving treatment for cerebral infarction underwent an esophagogastroduodenoscopy (EGD) for suspicion of gastrointestinal bleeding. EGD revealed a type 0‑I protruding lesion in the lesser curvature of the upper gastric corpus. Biopsy indicated well‑differentiated adenocarcinoma. As the tumor diameter was >3 cm and the thickness of the tumor suggested submucosal invasion, laparoscopic gastrectomy was performed. Histological assessment revealed polypoid growth of an intramucosal, differentiated, tubular or papillary adenocarcinoma, with dense infiltration of lymphocytes. The carcinoma crypts were found to be EBV‑positive on in situ hybridization. A review of the clinicopathological features of 25 EBV‑associated GCs from 20 patients treated in our hospital between 2005 and 2014 was performed. All of these tumors, except that in the current case, appeared as shallow, depressed or ulcerative lesions. Thus, the current case appears to represent an unusual growth of EBV-positive GC.
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May 2018
Volume 8 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N. ... Ohmiya, N. (2018). Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report. Molecular and Clinical Oncology, 8, 657-660. https://doi.org/10.3892/mco.2018.1586
MLA
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N., Nakagawa, Y., Nagasaka, M., Nakagawa, M., Tsukamoto, T., Shibata, T., Ohmiya, N."Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report". Molecular and Clinical Oncology 8.5 (2018): 657-660.
Chicago
Horiguchi, N., Tahara, T., Kawamura, T., Okubo, M., Ishizuka, T., Nakano, N., Nakagawa, Y., Nagasaka, M., Nakagawa, M., Tsukamoto, T., Shibata, T., Ohmiya, N."Unusual growth of an Epstein-Barr virus-associated differentiated early-stage gastric carcinoma: A case report". Molecular and Clinical Oncology 8, no. 5 (2018): 657-660. https://doi.org/10.3892/mco.2018.1586