‘Blastoid’ variant of Burkitt lymphoma with additional partial 1q tetrasomy
- Ahsan Siddiqi
- Sheshadri Madhusudhana
- Alexey Glazyrin
Affiliations: Department of Pathology, Truman Medical Centers-Hospital Hill, Kansas City, MO 64108, USA, Department of Hematology/Oncology, Truman Medical Centers-Hospital Hill, Kansas City, MO 64108, USA
- Published online on: March 5, 2018 https://doi.org/10.3892/mco.2018.1585
Copyright: © Siddiqi
et al. This is an open access article distributed under the
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Burkitt lymphoma is cytogenetically characterized by t(8;14)(q24;q32) translocation, sometimes accompanied by additional cytogenetic abnormalities. These abnormalities usually result in more aggressive clinical presentation and morphology of the disease. The current report presens a case of Burkitt lymphoma with t(8;14)(q24;q32) accompanied by partial tetrasomy of chromosome 1(47,XY,+1,i(1)(q10),t(8;14)(q24;q32)/46,XY). The patient was a 59-year-old male who presented with abdominal pain, leukocytosis and tumor lysis syndrome. No lymphadenopathy was noted. Cerebrospinal fluid analysis revealed atypical lymphocytes. A peripheral blood smear revealed tumor cells exhibiting distinct ‘blastoid’ morphology: Prominent nucleoli, basophilic cytoplasm, occasional cytoplasmic vacuoles. Flow cytometry demonstrated B cells expressing cluster of differentiation (CD)10 and cytoplasmic kappa light chain restriction without surface expression of immunoglobulins and CD20. A bone marrow biopsy revealed hematopoiesis, with a 90% replacement with atypical lymphocytes. The patient was treated with chemotherapy. Following the first cycle of treatment, the patient developed neutropenic fever, bacteremia and died a few days later. Gain of chromosome 1q in addition to characteristic for Burkitt lymphoma t(8;14)(q24;q32) resulted in immature ‘blastoid’ morphology and the immunophenotype of tumor cells, leukemic presentation without lymph node involvement and a highly aggressive clinical course.