Open Access

‘Blastoid’ variant of Burkitt lymphoma with additional partial 1q tetrasomy

  • Authors:
    • Ahsan Siddiqi
    • Sheshadri Madhusudhana
    • Alexey Glazyrin
  • View Affiliations

  • Published online on: March 5, 2018     https://doi.org/10.3892/mco.2018.1585
  • Pages: 637-639
  • Copyright: © Siddiqi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Burkitt lymphoma is cytogenetically characterized by t(8;14)(q24;q32) translocation, sometimes accompanied by additional cytogenetic abnormalities. These abnormalities usually result in more aggressive clinical presentation and morphology of the disease. The current report presens a case of Burkitt lymphoma with t(8;14)(q24;q32) accompanied by partial tetrasomy of chromosome 1(47,XY,+1,i(1)(q10),t(8;14)(q24;q32)[2]/46,XY[18]). The patient was a 59-year-old male who presented with abdominal pain, leukocytosis and tumor lysis syndrome. No lymphadenopathy was noted. Cerebrospinal fluid analysis revealed atypical lymphocytes. A peripheral blood smear revealed tumor cells exhibiting distinct ‘blastoid’ morphology: Prominent nucleoli, basophilic cytoplasm, occasional cytoplasmic vacuoles. Flow cytometry demonstrated B cells expressing cluster of differentiation (CD)10 and cytoplasmic kappa light chain restriction without surface expression of immunoglobulins and CD20. A bone marrow biopsy revealed hematopoiesis, with a 90% replacement with atypical lymphocytes. The patient was treated with chemotherapy. Following the first cycle of treatment, the patient developed neutropenic fever, bacteremia and died a few days later. Gain of chromosome 1q in addition to characteristic for Burkitt lymphoma t(8;14)(q24;q32) resulted in immature ‘blastoid’ morphology and the immunophenotype of tumor cells, leukemic presentation without lymph node involvement and a highly aggressive clinical course.
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May 2018
Volume 8 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Siddiqi, A., Madhusudhana, S., & Glazyrin, A. (2018). ‘Blastoid’ variant of Burkitt lymphoma with additional partial 1q tetrasomy. Molecular and Clinical Oncology, 8, 637-639. https://doi.org/10.3892/mco.2018.1585
MLA
Siddiqi, A., Madhusudhana, S., Glazyrin, A."‘Blastoid’ variant of Burkitt lymphoma with additional partial 1q tetrasomy". Molecular and Clinical Oncology 8.5 (2018): 637-639.
Chicago
Siddiqi, A., Madhusudhana, S., Glazyrin, A."‘Blastoid’ variant of Burkitt lymphoma with additional partial 1q tetrasomy". Molecular and Clinical Oncology 8, no. 5 (2018): 637-639. https://doi.org/10.3892/mco.2018.1585