Association between MDM2‑SNP309 and p53R72P polymorphisms and the risk of bladder cancer in the Mongolian population

  • Authors:
    • Shiirevnyamba Avirmed
    • Bo‑Shen Wang
    • Baasansuren Selenge
    • Amarsaikhan Sanjaajamts
    • Batmunkh Ganbat
    • Ulziisaikhan Erdenebileg
    • Myagmarsuren Purevsuren
    • Sarantsetseg Jigjidsuren
    • Munkhbat Batmunkh
    • Yi‑Jang Lee
  • View Affiliations

  • Published online on: July 13, 2017     https://doi.org/10.3892/mco.2017.1317
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Abstract

The current study aims to investigate whether MDM2‑SNP309 and p53R72P polymorphisms were associated with the risk of bladder cancer in Mongolian populations. These polymorphisms were evaluated in 79 controls and 63 bladder cancer cases using a PCR‑restriction fragment length polymorphism assay, followed by analysis using multivariate logistic regression model and the Kaplan‑Meier model to determine the odds ratio (OR) and age at onset of bladder cancer, respectively. The results revealed that the homozygous (G/G) genotype of MDM2‑SNP309 increased the risk of bladder cancer compared to the wild‑type (T/T) genotype [OR=1.629; 95% confidence interval (CI)=0.622‑4.266] among Mongolians. On the other hand, the homozygous (P/P) genotype of p53R72P tended to protect the population from bladder cancer compared with the wild‑type (R/R) genotype (OR=0.445; 95% CI=0.1727‑2.147). It also showed that G/G genotype of MDM2‑SNP309 increased the risk of bladder cancer when combined with the R/R genotype of p53R72P (OR=3.355; 95% CI=0.3914‑28.766). Stratification by smoking and history of chronic urinary tract diseases tended towards increasing the risk association of the G/G (OR=2.3704; 95% CI=0.4308‑3.044) and T/G genotypes (OR=5; 95% CI=0.8442‑30.4088) of MDM2‑SNP309 with bladder cancer, respectively. The protective role of P/P of p53R72P remained following stratification. MDM2‑SNP309 and p53R72P were not involved in early age onset of bladder cancer in Mongolian patients. Taken together, MDM2‑SNP309 and p53R72P had no significant association with bladder cancer in Mongolian patients. The two SNPs were also not able to predict early age at onset of bladder cancer.

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APA
Avirmed, S., Wang, B., Selenge, B., Sanjaajamts, A., Ganbat, B., Erdenebileg, U. ... Lee, Y. (1899). Association between MDM2‑SNP309 and p53R72P polymorphisms and the risk of bladder cancer in the Mongolian population. Molecular and Clinical Oncology, 0, 0-0. https://doi.org/10.3892/mco.2017.1317
MLA
Avirmed, S., Wang, B., Selenge, B., Sanjaajamts, A., Ganbat, B., Erdenebileg, U., Purevsuren, M., Jigjidsuren, S., Batmunkh, M., Lee, Y."Association between MDM2‑SNP309 and p53R72P polymorphisms and the risk of bladder cancer in the Mongolian population". Molecular and Clinical Oncology 0.0 (1899): 0-0.
Chicago
Avirmed, S., Wang, B., Selenge, B., Sanjaajamts, A., Ganbat, B., Erdenebileg, U., Purevsuren, M., Jigjidsuren, S., Batmunkh, M., Lee, Y."Association between MDM2‑SNP309 and p53R72P polymorphisms and the risk of bladder cancer in the Mongolian population". Molecular and Clinical Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/mco.2017.1317