68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review

  • Authors:
    • Lars J. Petersen
    • Julie B. Nielsen
    • Katja Dettmann
    • Rune V. Fisker
    • Uwe Haberkorn
    • Louise Stenholt
    • Helle D. Zacho
  • View Affiliations

  • Published online on: May 31, 2017     https://doi.org/10.3892/mco.2017.1280
  • Pages: 67-72
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Abstract

Localization of prostate cancer recurrence, particularly in the bones, is a major challenge with standard of care imaging in patients with biochemical recurrence following curatively intended treatment. Gallium‑68‑labeled prostate specific membrane antigen positron emission tomography/computed tomography (68Ga‑PSMA PET/CT) is a novel and promising method for imaging in prostate cancer. The present study reports two cases of patients with prostate cancer with biochemical recurrence, with evidence of bone metastases on 68Ga‑PSMA PET/CT images and low prostate specific antigen PSA levels (<2 ng/ml) and PSA doubling time >6 months. The bone metastases were verified by supplementary imaging with 18F‑sodium fluoride PET/CT and magnetic resonance imaging as well as biochemical responses to androgen deprivation therapy. Therefore, 68Ga‑PSMA PET/CT is promising for the restaging of patients with prostate cancer with biochemical recurrence, including patients with low PSA levels and low PSA kinetics.
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July 2017
Volume 7 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Petersen, L.J., Nielsen, J.B., Dettmann, K., Fisker, R.V., Haberkorn, U., Stenholt, L., & Zacho, H.D. (2017). 68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review. Molecular and Clinical Oncology, 7, 67-72. https://doi.org/10.3892/mco.2017.1280
MLA
Petersen, L. J., Nielsen, J. B., Dettmann, K., Fisker, R. V., Haberkorn, U., Stenholt, L., Zacho, H. D."68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review". Molecular and Clinical Oncology 7.1 (2017): 67-72.
Chicago
Petersen, L. J., Nielsen, J. B., Dettmann, K., Fisker, R. V., Haberkorn, U., Stenholt, L., Zacho, H. D."68Ga-PSMA PET/CT for the detection of bone metastasis in recurrent prostate cancer and a PSA level <2 ng/ml: Two case reports and a literature review". Molecular and Clinical Oncology 7, no. 1 (2017): 67-72. https://doi.org/10.3892/mco.2017.1280