Asbestos-related lung cancers: A retrospective clinical and pathological study

  • Authors:
    • Marie Uguen
    • Jean‑Dominique Dewitte
    • Pascale Marcorelles
    • Brice Loddé
    • Richard Pougnet
    • Philippe Saliou
    • Marc De Braekeleer
    • Arnaud Uguen
  • View Affiliations

  • Published online on: May 30, 2017     https://doi.org/10.3892/mco.2017.1277
  • Pages: 135-139
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Abstract

Exposure to asbestos results in serious risks of developing mesothelioma and lung cancer. The link between asbestos exposure and lung carcinoma is well established. Nevertheless, precise histopathological data are poorly considered when investigating the asbestos‑cancer link in a compensatory approach. In the present study, we aim to describe the features of individuals with compensated lung cancer who were referred to an occupational disease center, regarding occupational exposure to asbestos, smoking history and pathological data. We led a retrospective study of compensated ARLC cases seen in our occupational disease center between 2003 and 2013. A total of 146 men were included (mean age at diagnosis, 63.2 years) of whom approximately 90% were heavy current or former smokers (mean value, 30.4 packs/year). The major industries associated with the lung cancer cases were shipbuilding (69.9%), and building construction (7.5%) in this harbor region. The results of the present study showed that lung upper lobe was most prevalent (61.6%) and an excess of adenocarcinoma was found (45.9%), followed by squamous cell carcinoma (38.4%) as well as thoracic sarcomas (2.1%). Neoplasm was not histologically proven in 6.8% of the cases. Subsequent pathology examinations also reclassified 2 tumors as metastases from esophageal and laryngeal origins. In conclusion, smoking prevention should be encouraged in asbestos‑exposed workers as reflected by the number of smokers with asbestos‑related lung cancer. Thus, histological data should be considered further to evaluate the potent relationship between asbestos exposure and lung malignancy, especially in a compensatory approach.
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July 2017
Volume 7 Issue 1

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APA
Uguen, M., Dewitte, J., Marcorelles, P., Loddé, B., Pougnet, R., Saliou, P. ... Uguen, A. (2017). Asbestos-related lung cancers: A retrospective clinical and pathological study. Molecular and Clinical Oncology, 7, 135-139. https://doi.org/10.3892/mco.2017.1277
MLA
Uguen, M., Dewitte, J., Marcorelles, P., Loddé, B., Pougnet, R., Saliou, P., De Braekeleer, M., Uguen, A."Asbestos-related lung cancers: A retrospective clinical and pathological study". Molecular and Clinical Oncology 7.1 (2017): 135-139.
Chicago
Uguen, M., Dewitte, J., Marcorelles, P., Loddé, B., Pougnet, R., Saliou, P., De Braekeleer, M., Uguen, A."Asbestos-related lung cancers: A retrospective clinical and pathological study". Molecular and Clinical Oncology 7, no. 1 (2017): 135-139. https://doi.org/10.3892/mco.2017.1277