Factors favouring long‑term survival following recurrence in ovarian cancer

  • Authors:
    • Hiroaki Soyama
    • Masashi Takano
    • Morikazu Miyamoto
    • Tomoyuki Yoshikawa
    • Tadashi Aoyama
    • Tomoko Goto
    • Junko Hirata
    • Ayako Suzuki
    • Hidenori Sasa
    • Kenichi Furuya
  • View Affiliations

  • Published online on: May 17, 2017     https://doi.org/10.3892/mco.2017.1266
  • Pages: 42-46
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Abstract

The aim of the present study was to identify clinicopathological factors in long‑term survivors following ovarian cancer recurrence. The patients who achieved longer survival after recurrence (n=18) and those who succumbed to the disease earlier (n=47) were identified and analyzed. There were no significant differences in age, performance status, stage distribution or histology between the two groups. Additionally, no significant difference was observed in progression‑free survival after primary therapy. Multivariate analyses revealed that the predictive factors for long‑term survival were i) secondary debulking surgery (OR=13.3; 95% CI: 1.39‑226.7), ii) favourable response rate of second‑line chemotherapy (OR=46.5; 95% CI: 1.84‑313‑4), and iii) ≥3 regimens after first recurrence (OR=9.01; 95% CI: 1.28‑117.7). This study revealed that prolonged post‑progression survival was associated with post‑recurrence treatment. Therefore, appropriate selection of secondary debulking surgery and better chemotherapeutic response may lead to prolonged post‑progression survival in recurrent ovarian cancer patients.
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July 2017
Volume 7 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T. ... Furuya, K. (2017). Factors favouring long‑term survival following recurrence in ovarian cancer. Molecular and Clinical Oncology, 7, 42-46. https://doi.org/10.3892/mco.2017.1266
MLA
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T., Hirata, J., Suzuki, A., Sasa, H., Furuya, K."Factors favouring long‑term survival following recurrence in ovarian cancer". Molecular and Clinical Oncology 7.1 (2017): 42-46.
Chicago
Soyama, H., Takano, M., Miyamoto, M., Yoshikawa, T., Aoyama, T., Goto, T., Hirata, J., Suzuki, A., Sasa, H., Furuya, K."Factors favouring long‑term survival following recurrence in ovarian cancer". Molecular and Clinical Oncology 7, no. 1 (2017): 42-46. https://doi.org/10.3892/mco.2017.1266