Anorectal functional outcome following laparoscopic low anterior resection for rectal cancer

  • Authors:
    • Li‑Guo Liu
    • Xue‑Bing Yan
    • Ze‑Zhi Shan
    • Lei‑Lei Yan
    • Chun‑Yu Jiang
    • Jia Zhou
    • Yuan Tian
    • Zhi‑Ming Jin
  • View Affiliations

  • Published online on: March 8, 2017     https://doi.org/10.3892/mco.2017.1183
  • Pages: 613-621
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Abstract

Low anterior resection (LAR) with total mesorectal excision has been considered a standard treatment for patients with rectal cancer. However, the functional outcome and life quality of laparoscopic LAR (LLAR) in Chinese patients remain unclear. A cohort of 51 Chinese patients (22 men and 29 women) who had undergone LLAR was included in this study. Anorectal manometry combined with the Wexner scores questionnaire were applied to assess functional outcome preoperatively (1 week) and postoperatively (at 3, 6 and 9 months). The validated Chinese versions of the European Organization for Research and Treatment of Cancer QLQ‑C30 and QLQ‑CR38 questionnaires were also used to assess the patients' quality of life at the indicated time points. The results demonstrated that the manometric parameters exhibited a temporary decrease at 3 months postoperatively, but a gradual increase at 6 and 9 months, while the Wexner scores exhibited an opposite trend. Furthermore, patients with high anastomoses had significantly higher manometric parameters, a lower frequency of incontinence and lower Wexner scores compared with those with low anastomoses at 9 months (all P<0.05). For the entire cohort, quality of life at 3 months postoperatively was worse compared with the preoperative level, but returned to normal by 9 months. Patients with high anastomoses exhibited significantly better role, emotional and social function, had a better body image and sexual function, fewer problems with defecation and lower frequency of diarrhea, as well as fewer chemotherapy‑related side effects at 6 months postoperatively when compared with the low anastomosis group (all P<0.05). In conclusion, LLAR is generally acceptable for Chinese patients with rectal cancer, particularly for those with middle or high rectal cancer, in terms of functional outcome and quality of life.
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April 2017
Volume 6 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Liu, L., Yan, X., Shan, Z., Yan, L., Jiang, C., Zhou, J. ... Jin, Z. (2017). Anorectal functional outcome following laparoscopic low anterior resection for rectal cancer. Molecular and Clinical Oncology, 6, 613-621. https://doi.org/10.3892/mco.2017.1183
MLA
Liu, L., Yan, X., Shan, Z., Yan, L., Jiang, C., Zhou, J., Tian, Y., Jin, Z."Anorectal functional outcome following laparoscopic low anterior resection for rectal cancer". Molecular and Clinical Oncology 6.4 (2017): 613-621.
Chicago
Liu, L., Yan, X., Shan, Z., Yan, L., Jiang, C., Zhou, J., Tian, Y., Jin, Z."Anorectal functional outcome following laparoscopic low anterior resection for rectal cancer". Molecular and Clinical Oncology 6, no. 4 (2017): 613-621. https://doi.org/10.3892/mco.2017.1183