Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report

  • Authors:
    • Seyed Mehdi Hashemi
    • Shokoufeh Mahmoudi Shan
    • Mahdi Jahantigh
    • Abolghasem Allahyari
  • View Affiliations

  • Published online on: January 3, 2017     https://doi.org/10.3892/mco.2017.1124
  • Pages: 271-275
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Abstract

Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. In the present case report, we report on a middle-aged woman with a 2year history of acute myeloid leukemia (AML) who was admitted to hospital due to a mass in the right breast, with concurrent cutaneous lesions on the breast. The clinical and pathological investigations resulted in the diagnosis of adenosquamous carcinoma of the breast. The patient underwent a modified radical mastectomy (MRM). Subsequently, the patient received chemotherapy, involved-field radiation therapy and target therapy. At 9 months after the final cycle of chemotherapy, and while she was on targeted therapy with trastuzumab (6 mg administered every 3 weeks), the patient presented with extensive dermatomal skin lesions. A biopsy report revealed metastatic lesions of invasive ductal carcinoma in the abdomen, so chemotherapy resumed with a course lasting for 6 cycles, with the identical treatments, but lacking trastuzumab.
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February 2017
Volume 6 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Hashemi, S., Mahmoudi Shan, S., Jahantigh, M., & Allahyari, A. (2017). Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report. Molecular and Clinical Oncology, 6, 271-275. https://doi.org/10.3892/mco.2017.1124
MLA
Hashemi, S., Mahmoudi Shan, S., Jahantigh, M., Allahyari, A."Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report". Molecular and Clinical Oncology 6.2 (2017): 271-275.
Chicago
Hashemi, S., Mahmoudi Shan, S., Jahantigh, M., Allahyari, A."Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report". Molecular and Clinical Oncology 6, no. 2 (2017): 271-275. https://doi.org/10.3892/mco.2017.1124