The role of microRNAs in gallbladder cancer (Review)

  • Authors:
    • Ganghua Yang
    • Lei Zhang
    • Ruixiang Li
    • Lin Wang
  • View Affiliations

  • Published online on: May 11, 2016     https://doi.org/10.3892/mco.2016.905
  • Pages: 7-13
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Abstract

MicroRNAs (also referred to as miRNAs or miRs) play a crucial role in post-transcriptional gene regulation and serve as negative gene regulators by controlling a variety of target genes and regulating diverse biological processes, such as cell proliferation, invasion, migration and apoptosis. Aberrant expression of miRNAs is associated with the development and progression of cancer. Recent studies have reported that miRNAs may repress or promote the expression of cancer-related genes via several different signaling pathways in gallbladder cancer (GBC) patients and may function as tumor suppressors or oncogenes, thus providing a promising tool for the diagnosis and therapeutics of GBCs. In this review, we summarize the role of dysregulawted miRNA expression in the signaling pathways implicated in GBC and discuss the significant role of circulating miRNAs in GBC. Therefore, miRNAs may serve as novel therapeutic targets as well as diagnostic or prognostic markers in GBC.
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July 2016
Volume 5 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
APA
Yang, G., Zhang, L., Li, R., & Wang, L. (2016). The role of microRNAs in gallbladder cancer (Review). Molecular and Clinical Oncology, 5, 7-13. https://doi.org/10.3892/mco.2016.905
MLA
Yang, G., Zhang, L., Li, R., Wang, L."The role of microRNAs in gallbladder cancer (Review)". Molecular and Clinical Oncology 5.1 (2016): 7-13.
Chicago
Yang, G., Zhang, L., Li, R., Wang, L."The role of microRNAs in gallbladder cancer (Review)". Molecular and Clinical Oncology 5, no. 1 (2016): 7-13. https://doi.org/10.3892/mco.2016.905