Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study

  • Authors:
    • Filip Samal
    • Libor Stanek
    • Michal Filip
    • Pavel Haninec
    • Ales Vícha
    • Zdenek Musil
    • Petra Tesarova
    • Lubos Petruzelka
    • Drahomira Springer
    • Milena Kralickova
    • Milada Kohoutova
    • Tomas Zima
  • View Affiliations

  • Published online on: May 10, 2016     https://doi.org/10.3892/mco.2016.891
  • Pages: 161-164
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Abstract

The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non‑frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature.
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July 2016
Volume 5 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Samal, F., Stanek, L., Filip, M., Haninec, P., Vícha, A., Musil, Z. ... Zima, T. (2016). Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study. Molecular and Clinical Oncology, 5, 161-164. https://doi.org/10.3892/mco.2016.891
MLA
Samal, F., Stanek, L., Filip, M., Haninec, P., Vícha, A., Musil, Z., Tesarova, P., Petruzelka, L., Springer, D., Kralickova, M., Kohoutova, M., Zima, T."Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study". Molecular and Clinical Oncology 5.1 (2016): 161-164.
Chicago
Samal, F., Stanek, L., Filip, M., Haninec, P., Vícha, A., Musil, Z., Tesarova, P., Petruzelka, L., Springer, D., Kralickova, M., Kohoutova, M., Zima, T."Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study". Molecular and Clinical Oncology 5, no. 1 (2016): 161-164. https://doi.org/10.3892/mco.2016.891