Mutation of the nm23-H1 gene has a non-dominant role in colorectal adenocarcinoma

  • Authors:
    • Yueling Jin
    • Zhensheng Dai
  • View Affiliations

  • Published online on: May 9, 2016     https://doi.org/10.3892/mco.2016.889
  • Pages: 107-110
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Nm23-H1 is a metastasis suppressor gene, which is has a reduced expression in patients with digestive system cancer. However, the mechanistic basis for the genetic instability remains unknown. To study the expression of the nm23‑H1 gene in patients with colorectal cancer, polymerase chain reaction‑single strand conformation polymorphism was used to analyze any point mutation, and immunohistochemistry was used to detect the expression of nm23‑H1. Results revealed that all 63 specimens of Chinese human colorectal cancer tissues exhibit no point mutation. Among those 63 specimens, 19 (30%) exhibited positive immunostaining for the nm23‑H1 protein and 44 (70%) exhibited negative immunostaining. These observations suggested that the protein and gene expression levels of nm23‑H1 are reduced in colorectal cancer compared with the adjacent normal tissues, and the point mutation in the nm23‑H1 gene is not the dominant cause of metastatic colorectal cancer.
View Figures
View References

Related Articles

Journal Cover

July 2016
Volume 5 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Jin, Y., & Jin, Y. (2016). Mutation of the nm23-H1 gene has a non-dominant role in colorectal adenocarcinoma. Molecular and Clinical Oncology, 5, 107-110. https://doi.org/10.3892/mco.2016.889
MLA
Jin, Y., Dai, Z."Mutation of the nm23-H1 gene has a non-dominant role in colorectal adenocarcinoma". Molecular and Clinical Oncology 5.1 (2016): 107-110.
Chicago
Jin, Y., Dai, Z."Mutation of the nm23-H1 gene has a non-dominant role in colorectal adenocarcinoma". Molecular and Clinical Oncology 5, no. 1 (2016): 107-110. https://doi.org/10.3892/mco.2016.889