Sentinel lymph node biopsy reduces the incidence of secondary neck metastasis in patients with oral squamous cell carcinoma

  • Authors:
    • Akimitsu Hiraki
    • Daiki Fukuma
    • Masashi Nagata
    • Shinya Shiraishi
    • Kenta Kawahara
    • Yuichiro Matsuoka
    • Yoshihiro Nakagawa
    • Ryoji Yoshida
    • Takuya Tanaka
    • Yoshihiro Yoshitake
    • Masanori Shinohara
    • Yasuyuki Yamashita
    • Hideki Nakayama
  • View Affiliations

  • Published online on: April 28, 2016     https://doi.org/10.3892/mco.2016.882
  • Pages: 57-60
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Abstract

It has recently been established that sentinel node biopsy (SNB) is an applicable and feasible procedure for the prediction of neck lymph node status in patients with early oral squamous cell carcinoma (OSCC) who are clinically negative for neck metastasis (cN0). The aim of this study was to retrospectively compare excision followed by watchful waiting with excision and SNB, in order to determine the effectiveness of SNB. A total of 125 patients with cN0 early OSCC were divided into two groups, namely the excision alone (n=78) and excision with SNB (n=47) groups. The clinical data of these two groups between 2006 and 2013 were analyzed. In the excision with SNB group, the negative predictive value and false‑negative rate of SNB were 94% (30̸32) and 18% (2̸11), respectively. Secondary neck metastasis, also known as delayed neck metastasis, occurred in 24.2% of the patients in the excision alone group and 4.9% of the patients in the excision with SNB group. The 5‑year overall survival (OS) rates were 84.0 and 97.5% in the excision alone and excision with SNB groups, respectively. Significant differences were found in the rate of secondary neck metastasis and OS between the two groups. SNB may be effective in the detection of occult neck lymph node metastasis, with a reduction in the incidence of secondary neck metastasis and improvements in the 5-year OS in patients with early-stage (stage I̸II) oral cancer.
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July 2016
Volume 5 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Hiraki, A., Fukuma, D., Nagata, M., Shiraishi, S., Kawahara, K., Matsuoka, Y. ... Nakayama, H. (2016). Sentinel lymph node biopsy reduces the incidence of secondary neck metastasis in patients with oral squamous cell carcinoma. Molecular and Clinical Oncology, 5, 57-60. https://doi.org/10.3892/mco.2016.882
MLA
Hiraki, A., Fukuma, D., Nagata, M., Shiraishi, S., Kawahara, K., Matsuoka, Y., Nakagawa, Y., Yoshida, R., Tanaka, T., Yoshitake, Y., Shinohara, M., Yamashita, Y., Nakayama, H."Sentinel lymph node biopsy reduces the incidence of secondary neck metastasis in patients with oral squamous cell carcinoma". Molecular and Clinical Oncology 5.1 (2016): 57-60.
Chicago
Hiraki, A., Fukuma, D., Nagata, M., Shiraishi, S., Kawahara, K., Matsuoka, Y., Nakagawa, Y., Yoshida, R., Tanaka, T., Yoshitake, Y., Shinohara, M., Yamashita, Y., Nakayama, H."Sentinel lymph node biopsy reduces the incidence of secondary neck metastasis in patients with oral squamous cell carcinoma". Molecular and Clinical Oncology 5, no. 1 (2016): 57-60. https://doi.org/10.3892/mco.2016.882