Prognostic value of serum tumor abnormal protein in gastric cancer patients

  • Authors:
    • Feng Lan
    • Ming Zhu
    • Qiufeng Qi
    • Yaping Zhang
    • Yongping Liu
  • View Affiliations

  • Published online on: April 26, 2016     https://doi.org/10.3892/mco.2016.877
  • Pages: 216-220
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Aberrant glycosylation of protein occurs in nearly all types of cancers and has been confirmed to be associated with tumor progression, metastasis and the survival rate of patients. The present study aimed to explore the prognostic value of tumor abnormal protein (TAP) in gastric cancer patients. TAP was detected in the blood of 42 gastric cancer patients and 56 healthy volunteers by using the TAP testing kit. Univariate and multivariate Cox regression analysis were performed to evaluate the prognostic value of TAP. In total, 64.3% of gastric cancer patients were positive for TAP, and TAP was significantly correlated with poor prognosis [progression‑free survival (PFS), 4.2 vs. 12.6 months; P=0.043]. TAP [hazard ratio (HR), 64.487; P<0.01), differentiation (HR, 17.279; P<0.01) and TNM stage (HR, 45.480; P<0.01) were found to be independent predictive factors for PFS. Furthermore, Kaplan‑Meier curves indicated that TAP is associated with a reduced PFS in gastric cancer patients. The results of the present study therefore indicated that the TAP test has significant prognostic value for gastric cancer patients.
View Figures
View References

Related Articles

Journal Cover

July 2016
Volume 5 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Lan, F., Zhu, M., Qi, Q., Zhang, Y., & Liu, Y. (2016). Prognostic value of serum tumor abnormal protein in gastric cancer patients. Molecular and Clinical Oncology, 5, 216-220. https://doi.org/10.3892/mco.2016.877
MLA
Lan, F., Zhu, M., Qi, Q., Zhang, Y., Liu, Y."Prognostic value of serum tumor abnormal protein in gastric cancer patients". Molecular and Clinical Oncology 5.1 (2016): 216-220.
Chicago
Lan, F., Zhu, M., Qi, Q., Zhang, Y., Liu, Y."Prognostic value of serum tumor abnormal protein in gastric cancer patients". Molecular and Clinical Oncology 5, no. 1 (2016): 216-220. https://doi.org/10.3892/mco.2016.877