Association of MDM2 promoter T309G polymorphism with oral cancer risk: A meta-analysis of 3,536 subjects

  • Authors:
    • Xi Yang
    • Yun Zhu
    • Dongxia Ye
    • Yang Liu
    • Hongying Sun
    • Min Ruan
    • Wei Liu
  • View Affiliations

  • Published online on: April 20, 2016     https://doi.org/10.3892/mco.2016.868
  • Pages: 175-180
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Abstract

The mouse double minute 2 (MDM2) gene is an important regulator of the p53 suppressor gene. To date, evidence concerning the association of the MDM2 single nucleotide polymorphism (SNP) 309T>G (rs2279744) with the risk of developing oral squamous cell carcinoma (OSCC) remains controversial. Therefore, a meta‑analysis of all the eligible studies was performed, in order to derive a more precise estimation of this association. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the degree of association in 5 previous studies, including a total of 1,369 OSCC cases and 2,167 controls. The overall analysis revealed a significant association between MDM2 SNP309 and OSCC risk in the heterozygote (TG vs. TT: OR=0.81; 95% CI: 0.68‑0.96; P=0.02) and dominant models (TG+GG vs. TT: OR=0.82; 95% CI: 0.69‑0.97; P=0.02). The subgroup analysis based on the source of the controls revealed a significant association between population‑based controls and the heterozygote model (TG vs. TT: OR=0.75; 95% CI: 0.62‑0.91; P=0.004), dominant model (TG+GG vs. TT: OR=0.76; 95% CI: 0.63‑0.91; P=0.003) and allele comparison (G vs. T: OR=0.89; 95% CI: 0.79‑0.99; P=0.04). Importantly, no evidence of publication bias or obvious heterogeneity were observed in the meta‑analysis. The results of the present study demonstrated a decreased risk of developing OSCC for the MDM2 SNP309 group, suggesting MDM2 SNP309 may be a protection-associated genetic variation for OSCC. Additional well-designed studies, with larger sample sizes, are required to further elucidate this association.
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July 2016
Volume 5 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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APA
Yang, X., Zhu, Y., Ye, D., Liu, Y., Sun, H., Ruan, M., & Liu, W. (2016). Association of MDM2 promoter T309G polymorphism with oral cancer risk: A meta-analysis of 3,536 subjects. Molecular and Clinical Oncology, 5, 175-180. https://doi.org/10.3892/mco.2016.868
MLA
Yang, X., Zhu, Y., Ye, D., Liu, Y., Sun, H., Ruan, M., Liu, W."Association of MDM2 promoter T309G polymorphism with oral cancer risk: A meta-analysis of 3,536 subjects". Molecular and Clinical Oncology 5.1 (2016): 175-180.
Chicago
Yang, X., Zhu, Y., Ye, D., Liu, Y., Sun, H., Ruan, M., Liu, W."Association of MDM2 promoter T309G polymorphism with oral cancer risk: A meta-analysis of 3,536 subjects". Molecular and Clinical Oncology 5, no. 1 (2016): 175-180. https://doi.org/10.3892/mco.2016.868